The Interplay of Catalysis and Toxicity by Amyloid Intermediates on Lipid Bilayers: Insights from Type II Diabetes
Hebda JA, Miranker AD. The Interplay of Catalysis and Toxicity by Amyloid Intermediates on Lipid Bilayers: Insights from Type II Diabetes. Annual Review Of Biophysics 2009, 38: 125-152. PMID: 19416063, DOI: 10.1146/annurev.biophys.050708.133622.Peer-Reviewed Original ResearchConceptsAmyloid fibersLipid bilayersAlpha-helical stateAmyloid intermediatesProtein foldingBeta-sheet formationDevelopment of therapeuticsBiological functionsProtein precursorIntermediate speciesMolecular levelIonic homeostasisClass of diseasesFibrillar stateMature fibersType II diabetesCatalysisSpeciesCytotoxic speciesIntermediatesAffected tissuesII diabetesBilayersPrecursorsRecent advancesMetal binding sheds light on mechanisms of amyloid assembly
Calabrese MF, Miranker AD. Metal binding sheds light on mechanisms of amyloid assembly. Prion 2009, 3: 1-4. PMID: 19377278, PMCID: PMC2676736, DOI: 10.4161/pri.3.1.8601.Peer-Reviewed Original Research