2017
Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network
Martins A, Narayanan M, Prüstel T, Fixsen B, Park K, Gottschalk R, Lu Y, Andrews-Pfannkoch C, Lau W, Wendelsdorf K, Tsang J. Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network. Cell Systems 2017, 4: 379-392.e12. PMID: 28365150, PMCID: PMC8392141, DOI: 10.1016/j.cels.2017.03.002.Peer-Reviewed Original ResearchMeSH KeywordsComputer SimulationGene ExpressionGene Expression RegulationGene Regulatory NetworksGenetic VariationHumansInterleukin-10MacrophagesStochastic ProcessesConceptsGene networksCellular adaptationCell variationSingle-cell transcriptomic studiesGene-gene correlationsUnderlying regulatory mechanismsDegree of phosphorylationPhenotypic diversityTranscriptomic studiesEnvironmental adaptationMultiple molecular parametersGene expressionRegulatory mechanismsCellular heterogeneityDistinct environmentsSingle cellsHuman macrophagesQuantitative tuningCell populationsNatural perturbationsGenesDifferent environmentsSuch variationCellsStochastic simulation analysis
2012
Recent progress using systems biology approaches to better understand molecular mechanisms of immunity
Gottschalk R, Martins A, Sjoelund V, Angermann B, Lin B, Germain R. Recent progress using systems biology approaches to better understand molecular mechanisms of immunity. Seminars In Immunology 2012, 25: 201-208. PMID: 23238271, PMCID: PMC3834012, DOI: 10.1016/j.smim.2012.11.002.Commentaries, Editorials and LettersMeSH KeywordsAnimalsFeedback, PhysiologicalGene Expression RegulationHumansImmunityReceptor Cross-TalkSignal TransductionSystems BiologyConceptsSystems biology approachBiology approachSingle-cell measurement technologiesTranscriptional networksSpatial regulationHigh-throughput data acquisitionMolecular mechanismsComputational integrationImmune systemFeedback loopNovel perturbationRecent progressSignalingReductionist researchRegulationBroad rangePotential sourceFunctionResponse heterogeneity
2010
Lactobacillus rhamnosus GR-1 Stimulates Colony-Stimulating Factor 3 (Granulocyte) (CSF3) Output in Placental Trophoblast Cells in a Fetal Sex-Dependent Manner1
Yeganegi M, Leung C, Martins A, Kim S, Reid G, Challis J, Bocking A. Lactobacillus rhamnosus GR-1 Stimulates Colony-Stimulating Factor 3 (Granulocyte) (CSF3) Output in Placental Trophoblast Cells in a Fetal Sex-Dependent Manner1. Biology Of Reproduction 2010, 84: 18-25. PMID: 20811016, PMCID: PMC4480822, DOI: 10.1095/biolreprod.110.085167.Peer-Reviewed Original ResearchConceptsPlacental trophoblast cellsTrophoblast cellsPreterm birthFetal sex-dependent mannerAnti-inflammatory effectsJanus kinaseSex-dependent mannerColony-stimulating factor 3Mitogen-activated protein kinase 14Western blot analysisPreterm laborPhosphorylation of STAT3Interleukin-10Bacterial vaginosisTherapeutic benefitFemale fetusesProtein kinase 14Placenta culturesAbsence of pretreatmentMAPK14 inhibitorSignal transducerTranscription 3Cell preparationsUnderlying mechanismBlot analysis