2018
Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism
Mao K, Baptista A, Tamoutounour S, Zhuang L, Bouladoux N, Martins A, Huang Y, Gerner M, Belkaid Y, Germain R. Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism. Nature 2018, 554: 255-259. PMID: 29364878, DOI: 10.1038/nature25437.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsCD4-Positive T-LymphocytesEpithelial CellsGastrointestinal MicrobiomeHomeodomain ProteinsHomeostasisImmunity, InnateInflammationInterleukin-23InterleukinsIntestine, SmallLipid MetabolismLymphocyte ActivationLymphocytesMaleMiceMonocytesPhosphorylationReceptors, CCR2STAT3 Transcription FactorSymbiosisTh17 CellsT-Lymphocytes, RegulatoryWeaning
2011
The anti-inflammatory role of granulocyte colony-stimulating factor in macrophage–dendritic cell crosstalk after Lactobacillus rhamnosus GR-1 exposure
Martins A, Spanton S, Sheikh H, Kim S. The anti-inflammatory role of granulocyte colony-stimulating factor in macrophage–dendritic cell crosstalk after Lactobacillus rhamnosus GR-1 exposure. Journal Of Leukocyte Biology 2011, 89: 907-915. PMID: 21385950, DOI: 10.1189/jlb.0810445.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCulture Media, ConditionedCytokinesDendritic CellsEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryGranulocyte Colony-Stimulating FactorInterleukin-12Interleukin-23Lacticaseibacillus rhamnosusMacrophagesMaleMAP Kinase Kinase 4MiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutP38 Mitogen-Activated Protein KinasesPhosphorylationReceptors, Granulocyte Colony-Stimulating FactorReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsIL-12 productionG-CSFIL-12P40 productionGr-1T cell stimulatory capacityIL-12/23 p40Cell stimulatory capacityAnti-inflammatory roleGranulocyte colony-stimulating factorCostimulatory molecules CD80Antibody-mediated neutralizationInnate immune systemColony-stimulating factorResponse of DCsSplenic DCsIL-23Cytokine profileStimulatory capacityIL-6Immune responseP40 subunitCell crosstalkP40 responseRG-CSF
2008
Reduced Expression of Basal and Probiotic-inducible G-CSF in Intestinal Mononuclear Cells Is Associated with Inflammatory Bowel Disease
Martins A, Colquhoun P, Reid G, Kim S. Reduced Expression of Basal and Probiotic-inducible G-CSF in Intestinal Mononuclear Cells Is Associated with Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2008, 15: 515-525. PMID: 19058228, DOI: 10.1002/ibd.20808.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEscherichia coliGranulocyte Colony-Stimulating FactorHumansInflammatory Bowel DiseasesInterleukin-12Interleukin-23Intestinal MucosaLacticaseibacillus rhamnosusLeukocytes, MononuclearMiceMice, Inbred C57BLMucous MembraneProbioticsReceptors, Granulocyte Colony-Stimulating FactorTumor Necrosis Factor-alphaConceptsGranulocyte-colony stimulating factorInflammatory bowel diseaseHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsG-CSF productionIntestinal mononuclear cellsBlood mononuclear cellsMononuclear cellsRhamnosus GR-1L. rhamnosus GR-1IL-23Bowel diseaseIntestinal lamina propria mononuclear cellsGr-1Intestinal lamina propria cellsLamina propria mononuclear cellsNon-IBD patientsReceptor knockout miceReceptor-deficient miceProinflammatory cytokine productionLamina propria cellsBone marrow-derived macrophagesIntestinal tissue samplesMarrow-derived macrophagesG-CSF release