CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection
Prendergast A, Jim K, Marnas H, Desban L, Quan F, Djenoune L, Laghi V, Hocquemiller A, Lunsford E, Roussel J, Keiser L, Lejeune F, Dhanasekar M, Bardet P, Levraud J, van de Beek D, Vandenbroucke-Grauls C, Wyart C. CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current Biology 2023, 33: 940-956.e10. PMID: 36791723, DOI: 10.1016/j.cub.2023.01.039.Peer-Reviewed Original ResearchConceptsCentral nervous systemCerebrospinal fluidSensory neuronsNervous systemStreptococcus pneumoniaeCentral nervous system infectionBlockade of neurotransmissionCentral sensory neuronsNervous system infectionHost survivalPeripheral nervous systemCell-specific ablationEpileptic-like seizuresCSF-contacting neuronsSupernatants of cellsPneumococcal meningitisSystem infectionBitter taste receptorsCSF infectionPneumoniae infectionNeurotropic virusesSpinal cordPathogenic bacteriaPostural controlMeningitis