2024
A mediation analysis framework based on variance component to remove genetic confounding effect
Dong Z, Zhao H, DeWan A. A mediation analysis framework based on variance component to remove genetic confounding effect. Journal Of Human Genetics 2024, 69: 301-309. PMID: 38528049, DOI: 10.1038/s10038-024-01232-x.Peer-Reviewed Original ResearchMediation analysis frameworkSingle nucleotide polymorphismsMediation analysisPleiotropic single nucleotide polymorphismsUK Biobank dataConfounding effectsTrait pairsBiobank dataIndividual-levelEpidemiological studiesCausal effectsGenetic signalsEstimated effectsLinear regressionNucleotide polymorphismsStandard errorData analysisGenetic correlationsPhenotypeIndirect effectsPleiotropyVariance componentsOutcomesRegression
2017
Statistical Analysis of Multiple Phenotypes in Genetic Epidemiologic Studies: From Cross-Phenotype Associations to Pleiotropy
Salinas YD, Wang Z, DeWan AT. Statistical Analysis of Multiple Phenotypes in Genetic Epidemiologic Studies: From Cross-Phenotype Associations to Pleiotropy. American Journal Of Epidemiology 2017, 187: 855-863. PMID: 29020254, PMCID: PMC5889027, DOI: 10.1093/aje/kwx296.Peer-Reviewed Original Research