2006
Neurobiology of Depression in Children and Adolescents
Zalsman G, Oquendo MA, Greenhill L, Goldberg PH, Kamali M, Martin A, Mann JJ. Neurobiology of Depression in Children and Adolescents. Child And Adolescent Psychiatric Clinics Of North America 2006, 15: 843-868. PMID: 16952764, DOI: 10.1016/j.chc.2006.05.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenocorticotropic HormoneAnxiety DisordersBrainChildCognitive Behavioral TherapyCorticotropin-Releasing HormoneDepressive DisorderEstradiolFemaleHuman Growth HormoneHumansHypothalamo-Hypophyseal SystemMagnetic Resonance ImagingMaleNeurotransmitter AgentsPituitary-Adrenal SystemPrevalencePubertyRisk FactorsTestosterone
2005
SSRIs and the developing brain
Ruchkin V, Martin A. SSRIs and the developing brain. The Lancet 2005, 365: 451-453. PMID: 15705440, DOI: 10.1016/s0140-6736(05)17877-5.Peer-Reviewed Original Research
2000
Pharmacotherapy of Early-Onset Depression Update and New Directions
Martin A, Kaufman J, Charney D. Pharmacotherapy of Early-Onset Depression Update and New Directions. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 135-157. PMID: 10674194, DOI: 10.1016/s1056-4993(18)30139-1.Peer-Reviewed Original ResearchConceptsEarly-onset depressionDepressive disorderSafety dataLong-term exposureBrain-derived neurotrophic factor levelsLong-term safety dataEarly-onset depressive disordersAvailable antidepressant agentsRigid treatment guidelinesUseful treatment interventionsNeurotrophic factor levelsLong-term followShort-term efficacyShort-term efficacy dataAtrophic brain changesHigh recurrence ratePsychopharmacology Algorithm ProjectRoutine clinical practiceAlternative treatment strategiesYears of ageShort-term trialsPaucity of dataRisk-benefit analysisLong-term useAntidepressant medication