Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder
KALMAR JH, WANG F, SPENCER L, EDMISTON E, LACADIE CM, MARTIN A, CONSTABLE RT, DUNCAN JS, STAIB LH, PAPADEMETRIS X, BLUMBERG HP. Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder. Journal Of The International Neuropsychological Society 2009, 15: 476-481. PMID: 19402934, PMCID: PMC2852397, DOI: 10.1017/s1355617709090584.Peer-Reviewed Original ResearchConceptsAdolescents/young adultsVentral prefrontal cortexBipolar disorderYoung adultsBrain volume changesRostral anterior cingulate cortexPrevious cross-sectional studiesCross-sectional studyAdolescence/young adulthoodHigh-resolution magnetic resonanceAnterior cingulate cortexPreliminary evidenceVolume abnormalitiesHealthy comparison participantsPrefrontal abnormalitiesGreater volume lossCingulate cortexRegional volumesPrefrontal cortexModest sample sizeYoung adulthoodAdultsRostral PFCComparison participantsAbnormalities