Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis
Reyes MM, Panza KE, Martin A, Bloch MH. Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 50: 63-72. PMID: 21156271, PMCID: PMC3645909, DOI: 10.1016/j.jaac.2010.10.008.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitorsPlacebo-controlled trialTime-lag biasMajor depressive disorderYears of ageReuptake inhibitorsAntidepressant trialsPediatric depressionDepressive disorderTreatment respondersMAIN OUTCOMESystematic reviewMeta-AnalysisPositive findingsNegative findingsNegative trialsMedical literatureAntidepressantsTrialsPublication of findingsNegative resultsChild psychiatryEfficacyFindingsPublication timeCharacterizing Declines in Pediatric Antidepressant Use After New Risk Disclosures
Busch SH, Frank RG, Martin A, Barry CL. Characterizing Declines in Pediatric Antidepressant Use After New Risk Disclosures. Medical Care Research And Review 2010, 68: 96-111. PMID: 20675349, PMCID: PMC2974787, DOI: 10.1177/1077558710374197.Peer-Reviewed Original ResearchConceptsAntidepressant usePediatric antidepressant useAntidepressant medication useNew treatment episodeNew safety informationRisk of suicidalityAntidepressant medicationMedication useTreatment patternsTreatment episodesHealth outcomesLatter groupChildrenSafety informationFamily characteristicsCollege-educated parentsExperienced declinesMedicationsAntidepressantsDeclineFindingsSuicidality