Childhood maltreatment and health in the UK Biobank: triangulation of outcome-wide and polygenic risk score analyses
Espinosa Dice A, Lawn R, Ratanatharathorn A, Roberts A, Denckla C, Kim A, de la Rosa P, Zhu Y, VanderWeele T, Koenen K. Childhood maltreatment and health in the UK Biobank: triangulation of outcome-wide and polygenic risk score analyses. BMC Medicine 2024, 22: 135. PMID: 38523269, PMCID: PMC10962116, DOI: 10.1186/s12916-024-03360-9.Peer-Reviewed Original ResearchConceptsOutcome-wide analysisUK BiobankBias due to unmeasured confoundingPolygenic risk score analysisPolygenic risk scoresPhysical health outcomesLower household incomeDirection of associationImprove causal inferenceRisk score analysisHearing difficultiesHealth behaviorsHealth outcomesHealth themesUnmeasured confoundersSocioeconomic statusDiastolic blood pressureAnalytic sampleTriangulation studySources of biasHousehold incomeRisk scoreTriangulation designChildhood maltreatmentGeneralized linear modelPolygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violence
Ratanatharathorn A, Quan L, Koenen K, Chibnik L, Weisskopf M, Slopen N, Roberts A. Polygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violence. Translational Psychiatry 2024, 14: 119. PMID: 38409192, PMCID: PMC10897413, DOI: 10.1038/s41398-024-02814-1.Peer-Reviewed Original ResearchConceptsAttention-deficit hyperactivity disorderAutism spectrum disorderMental illnessIntimate partner violenceBipolar disorderHyperactivity disorderGenetic riskAttention deficit hyperactivity disorderGene-environment correlationPartner violenceDeficit hyperactivity disorderDepressive disorderPolygenic risk scoresSpectrum disorderPolygenic riskNeuroticismMDDDisordersIllnessWomen of European ancestryExperience of intimate partner violenceViolenceSchizophreniaAutismDepression