2023
Grading system for medullary thyroid carcinoma; an institutional experience
Podany P, Meiklejohn K, Garritano J, Holt E, Barbieri A, Prasad M, Gilani S. Grading system for medullary thyroid carcinoma; an institutional experience. Annals Of Diagnostic Pathology 2023, 64: 152112. PMID: 36736129, DOI: 10.1016/j.anndiagpath.2023.152112.Peer-Reviewed Original ResearchConceptsMedullary thyroid carcinomaTwo-tier grading systemDistant metastasisNuclear pleomorphismGrading systemNodal diseaseOverall survivalVascular invasionMTC casesThyroid carcinomaMedullary thyroid carcinoma casesMultivariate Cox regressionThyroid carcinoma casesCohort of casesRisk stratificationCox regressionTumor gradePathology reportsCarcinoma casesInstitutional experienceThyroid malignancyTumor fibrosisHG groupProminent nucleoliRare type
2021
Impact of Transoral Endoscopic Vestibular Approach Thyroidectomy on Pathologic Assessment.
Smith SM, Ahmed M, Carling T, Udelsman R, Adeniran AJ, Gilani S, Prasad ML, Barbieri AL. Impact of Transoral Endoscopic Vestibular Approach Thyroidectomy on Pathologic Assessment. Archives Of Pathology & Laboratory Medicine 2021, 146: 879-885. PMID: 34669921, DOI: 10.5858/arpa.2021-0082-oa.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaMargin statusFinal diagnosisThyroid carcinomaCytologic diagnosisEndoscopic thyroid resectionUndetermined significance/Surgical resection specimensPreoperative cytologic diagnosisPathologic assessmentClinical followIndolent neoplasmClinicopathologic featuresThyroid resectionVestibular approachMean agePathologic examinationPreoperative imagingTumor sizeResection specimensPathologic parametersMalignant diagnosisFollicular lesionsFollicular neoplasmSurgical pathologyAnaplastic Thyroid Carcinoma: Cytomorphologic Features on Fine-Needle Aspiration and Associated Diagnostic Challenges
Podany P, Abi-Raad R, Barbieri A, Garritano J, Prasad ML, Cai G, Adeniran AJ, Gilani SM. Anaplastic Thyroid Carcinoma: Cytomorphologic Features on Fine-Needle Aspiration and Associated Diagnostic Challenges. American Journal Of Clinical Pathology 2021, 157: 608-619. PMID: 34661606, PMCID: PMC8973262, DOI: 10.1093/ajcp/aqab159.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAnaplastic thyroid carcinomaFine-needle aspirationCytologic featuresATC casesTumor cellsThyroid carcinomaControl groupDiagnosis of ATCAcute inflammatory cellsKey cytologic featuresNuclear membrane irregularitySingle tumor cellsAggressive malignancyInflammatory cellsClinical historyDiagnostic challengePatient prognosisInclusion criteriaNeedle aspirationCytomorphologic featuresEarly diagnosisEpithelioid cytomorphologyNuclear pleomorphismAvailable slidesElectronic databasesEpidermotropic metastasis of squamous cell carcinoma of the tonsil: A case report with molecular confirmation
Li P, Barbieri A, Walther Z, McNiff J, Panse G. Epidermotropic metastasis of squamous cell carcinoma of the tonsil: A case report with molecular confirmation. Journal Of Cutaneous Pathology 2021, 48: 1514-1519. PMID: 34302376, DOI: 10.1111/cup.14108.Peer-Reviewed Case Reports and Technical NotesConceptsSquamous cell carcinomaOropharyngeal squamous cell carcinomaCell carcinomaDe novo squamous cell carcinomaPrimary oropharyngeal squamous cell carcinomaTonsillar squamous cell carcinomaTargetable genetic aberrationsLesion biopsy specimensSkin biopsy specimenSkin lesion biopsy specimensMetastatic diseaseEpidermal involvementEpidermotropic metastasesMetastatic lesionsPoor prognosisBiopsy specimenCase reportClinical historyBiopsy specimensSecondary diseaseSkin lesionsTumor originMetastatic specimensMetastasisNeck skin
2020
Thyroid tissue outside the thyroid gland: Differential diagnosis and associated diagnostic challenges
Barbieri A, Prasad ML, Gilani SM. Thyroid tissue outside the thyroid gland: Differential diagnosis and associated diagnostic challenges. Annals Of Diagnostic Pathology 2020, 48: 151584. PMID: 32871503, DOI: 10.1016/j.anndiagpath.2020.151584.Peer-Reviewed Original ResearchConceptsDifferential diagnostic considerationsThyroid tissueThyroid glandLymph nodesDiagnostic challengeDifferential diagnosisDiagnostic considerationsLateral neck lymph nodesNeck lymph nodesRoutine daily practiceThyroglossal duct cystLocation of lesionsMalignant differential diagnosisDuct cystDefinitive diagnosisLingual thyroidAnatomic locationClinical settingThyroid folliclesDaily practiceDiagnosisParasitic nodulesGlandTissueHistologicHistologic Classification and Molecular Signature of Polymorphous Adenocarcinoma (PAC) and Cribriform Adenocarcinoma of Salivary Gland (CASG)
Xu B, Barbieri AL, Bishop JA, Chiosea SI, Dogan S, Di Palma S, Faquin WC, Ghossein R, Hyrcza M, Jo VY, Lewis JS, Lozada JR, Michal M, Pareja FG, Perez-Ordonez B, Prasad ML, Purgina B, Reis-Filho JS, Scognamiglio T, Sebastiao APM, Seethala RR, Skálová A, Smith SM, Tekkeşin MS, Thompson LDR, Wasseman JK, Wenig BM, Weinreb I, Katabi N. Histologic Classification and Molecular Signature of Polymorphous Adenocarcinoma (PAC) and Cribriform Adenocarcinoma of Salivary Gland (CASG). The American Journal Of Surgical Pathology 2020, 44: 545-552. PMID: 31917707, PMCID: PMC7437128, DOI: 10.1097/pas.0000000000001431.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBiomarkers, TumorBiopsyCanadaDNA Mutational AnalysisEuropeGene FusionGenetic Predisposition to DiseaseHumansIn Situ Hybridization, FluorescenceMutationObserver VariationPredictive Value of TestsReal-Time Polymerase Chain ReactionReproducibility of ResultsSalivary Gland NeoplasmsUnited StatesConceptsPapillary architectureIndeterminate featuresPolymorphous adenocarcinomaConsensus diagnosisCribriform adenocarcinomaInterobserver agreementSalivary glandsFair interobserver agreementNeck pathologistHistologic diversityHistologic classificationMorphologic spectrumDiagnostic concordanceSolid patternMolecular alterationsAdenocarcinomaGlomeruloid structuresTumorsLevel of agreementHotspot mutationsClear nucleiModerate agreementExpert pathologistsSuch molecular eventsMolecular signatures
2019
Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas
Patel N, Barbieri A, Gibson J. Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas. Surgical Pathology Clinics 2019, 12: 1021-1044. PMID: 31672292, DOI: 10.1016/j.path.2019.08.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGrading Pancreatic Neuroendocrine Tumors by Ki-67 Index Evaluated on Fine-Needle Aspiration Cell Block Material
Abi-Raad R, Lavik JP, Barbieri AL, Zhang X, Adeniran AJ, Cai G. Grading Pancreatic Neuroendocrine Tumors by Ki-67 Index Evaluated on Fine-Needle Aspiration Cell Block Material. American Journal Of Clinical Pathology 2019, 153: 74-81. PMID: 31415691, DOI: 10.1093/ajcp/aqz110.Peer-Reviewed Original Research
2018
Clonal evolution analysis of paired anaplastic and well‐differentiated thyroid carcinomas reveals shared common ancestor
Dong W, Nicolson NG, Choi J, Barbieri AL, Kunstman JW, Azar S, Knight J, Bilguvar K, Mane SM, Lifton RP, Korah R, Carling T. Clonal evolution analysis of paired anaplastic and well‐differentiated thyroid carcinomas reveals shared common ancestor. Genes Chromosomes And Cancer 2018, 57: 645-652. PMID: 30136351, DOI: 10.1002/gcc.22678.Peer-Reviewed Original ResearchConceptsCommon ancestorProgression of ATCClonal evolution analysisEvolutionary lineagesGenetic relationshipsAnaplastic thyroid carcinomaClonal analysisAncestorEvolution analysisPrivate mutationsMutationsATC tumorsLineal relationshipLineagesNormal tissuesThyroid carcinomaLandscapeFollicular thyroid carcinomaPairsSuccessful treatment of primary donor‐derived human herpesvirus‐8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient
Fu W, Merola J, Malinis M, Lacy J, Barbieri A, Liapakis AH, Mulligan DC, Yoo PS. Successful treatment of primary donor‐derived human herpesvirus‐8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient. Transplant Infectious Disease 2018, 20: e12966. PMID: 30014622, DOI: 10.1111/tid.12966.Peer-Reviewed Case Reports and Technical NotesConceptsHuman herpesvirus 8 infectionHepatic Kaposi sarcomaKaposi's sarcomaTransplant recipientsAdult liver transplant recipientsRegression of KSSplit liver transplantAcute cellular rejectionLiver transplant recipientsSuccessful therapeutic strategiesAllograft functionCellular rejectionLiver transplantSeropositive donorsSuccessful treatmentLiposomal doxorubicinTherapeutic strategiesRecipientsSarcomaInfectionTreatmentImmunosuppressionPatientsMalignancyTransplantOptimal Intraoperative Assessment of Gastric Margins
Celli R, Barbieri AL, Colunga M, Sinard J, Gibson JA. Optimal Intraoperative Assessment of Gastric Margins. American Journal Of Clinical Pathology 2018, 150: 353-363. PMID: 30020407, DOI: 10.1093/ajcp/aqy062.Peer-Reviewed Original ResearchConceptsIntraoperative pathology consultationGastric marginPositive marginsTumor distanceMajority of casesRepresentative sectionsR0 resectionConsecutive patientsGastroesophageal junctionTumor sizeNegative marginsPatient outcomesIntraoperative assessmentPathology consultationPatientsStrong associationMargin assessmentComprehensive Genetic Analysis of Follicular Thyroid Carcinoma Predicts Prognosis Independent of Histology
Nicolson NG, Murtha TD, Dong W, Paulsson JO, Choi J, Barbieri AL, Brown TC, Kunstman JW, Larsson C, Prasad ML, Korah R, Lifton RP, Juhlin CC, Carling T. Comprehensive Genetic Analysis of Follicular Thyroid Carcinoma Predicts Prognosis Independent of Histology. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2640-2650. PMID: 29726952, DOI: 10.1210/jc.2018-00277.Peer-Reviewed Original ResearchConceptsFollicular thyroid carcinomaThyroid carcinomaMutation burdenWorse disease-specific survivalDisease-specific survivalDifferent histopathological subtypesWorld Health Organization guidelinesSomatic mutationsNonsynonymous somatic mutationsHealth Organization guidelinesTotal mutation burdenIndependent predictorsWorse prognosisHistopathological subtypesPatient outcomesHistopathological classificationInvasive subtypesClinicopathologic parametersMutational burdenSurvival analysisSomatic copy number alterationsCopy number alterationsSubtypesOrganization guidelinesMore subclonesTranslocation of a gut pathobiont drives autoimmunity in mice and humans
Vieira S, Hiltensperger M, Kumar V, Zegarra-Ruiz D, Dehner C, Khan N, Costa FRC, Tiniakou E, Greiling T, Ruff W, Barbieri A, Kriegel C, Mehta SS, Knight JR, Jain D, Goodman AL, Kriegel MA. Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science 2018, 359: 1156-1161. PMID: 29590047, PMCID: PMC5959731, DOI: 10.1126/science.aar7201.Peer-Reviewed Original ResearchConceptsGut pathobiontAutoimmune-prone miceMurine findingsIntramuscular vaccinePathogenic autoantibodiesLiver biopsyAutoimmune responseAutoimmune patientsAntibiotic treatmentT cellsImmune diseasesAutoimmunitySusceptible humansPathobiontsSystemic tissuesHuman hepatocytesAutoantibodiesMortalityMiceCocultureHepatocytesGenetic backgroundTissueBiopsyPatients
2017
Two Cases of Primary Hepatic Neuroendocrine Tumors and a Review of the Current Literature
DeLuzio M, Barbieri A, Israel G, Emre S. Two Cases of Primary Hepatic Neuroendocrine Tumors and a Review of the Current Literature. Annals Of Hepatology 2017, 16: 621-629. PMID: 28611270, DOI: 10.5604/01.3001.0010.0313.Peer-Reviewed Original Research
2016
Evaluating Intestinal Infections
Barbieri A, West AB. Evaluating Intestinal Infections. Advances In Anatomic Pathology 2016, 23: 135-143. PMID: 27058242, DOI: 10.1097/pap.0000000000000111.Peer-Reviewed Original ResearchConceptsDifferential diagnosisEvidence of infectionEndoscopic biopsyIntestinal infectionsMucosal infectionsIntestinal mucosaHost reactionSmall intestineInfectious entitiesHistologic sectionsMorphologic compartmentsMucosaInfectionDiagnosisPathologistsPresent studyAutoimmuneCompartmentsBiopsyIntestine
2012
Comparison of PCR-based detection of chromogranin A mRNA with traditional histological lymph node staging of small intestinal neuroendocrine neoplasia
Lawrence B, Kenney B, Svejda B, Schimmack S, Alaimo D, Barbieri A, Jedrych J, Kidd M, Modlin I. Comparison of PCR-based detection of chromogranin A mRNA with traditional histological lymph node staging of small intestinal neuroendocrine neoplasia. BMC Research Notes 2012, 5: 318. PMID: 22720672, PMCID: PMC3441285, DOI: 10.1186/1756-0500-5-318.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorCarcinoma, NeuroendocrineChromogranin AFeasibility StudiesHumansImmunohistochemistryIntestinal NeoplasmsIntestine, SmallLymph NodesLymphatic MetastasisNeoplasm MicrometastasisNeoplasm StagingObserver VariationParaffin EmbeddingPredictive Value of TestsReal-Time Polymerase Chain ReactionReproducibility of ResultsRNA, MessengerTissue FixationConceptsLymph nodesCgA mRNALymph node metastasis detectionBenign gastrointestinal diseaseNon-neuroendocrine cancersSmall intestinal NENsDetection of chromograninGreater staging accuracyNode positivityGastrointestinal cancerNeuroendocrine differentiationHistological evidenceGastrointestinal diseasesImmunohistochemical stainingHistological examinationHistological lymphPathological analysisNeuroendocrine neoplasiaTherapeutic strategiesNormal epitheliumStaging accuracyTherapeutic interventionsMetastasis detectionTumor samplesAccurate therapeutic interventions
2011
Wagner-Meissner Corpuscle Proliferation
Barbieri AL, Jain D, Gobel S, Kenney B. Wagner-Meissner Corpuscle Proliferation. International Journal Of Surgical Pathology 2011, 20: 79-82. PMID: 21632642, DOI: 10.1177/1066896911408723.Peer-Reviewed Original Research