2022
Impact of secondary mitral regurgitation on survival in atrial and ventricular dysfunction
Mori M, Zogg C, Amabile A, Fereydooni S, Agarwal R, Weininger G, Krane M, Sugeng L, Geirsson A. Impact of secondary mitral regurgitation on survival in atrial and ventricular dysfunction. PLOS ONE 2022, 17: e0277385. PMID: 36548259, PMCID: PMC9778994, DOI: 10.1371/journal.pone.0277385.Peer-Reviewed Original ResearchConceptsSecondary mitral regurgitationVentricular dysfunctionHazard of deathAtrial dysfunctionMitral regurgitationMild secondary mitral regurgitationSevere secondary mitral regurgitationCox proportional hazards modelRisk-adjusted hazardRetrospective cohort studySurvival of patientsProportional hazards modelCohort studyPatient demographicsSeverity strataBetter survivalHazards modelPatientsDysfunctionNatural historyPropensity scoreSeverityDifferent severitySurvivalRegurgitationVariability in surveillance practice for patients with diagnosis of bicuspid aortic valve syndrome
Kahler-Quesada A, Vallabhajosyula I, Yousef S, Mori M, Amabile A, Assi R, Geirsson A, Vallabhajosyula P. Variability in surveillance practice for patients with diagnosis of bicuspid aortic valve syndrome. Scientific Reports 2022, 12: 22009. PMID: 36539583, PMCID: PMC9768129, DOI: 10.1038/s41598-022-25571-x.Peer-Reviewed Original ResearchConceptsBicuspid aortic valveTertiary care centerAortic valveCare centerCardiovascular specialistsBicuspid aortic valve syndromeAortic pathologySurveillance imagingDisease progressionPatientsBivariate analysisEchocardiogramGuide interventionDiagnosisHigher proportionValveSurveillance practicesUrgent needGuidelinesValvulopathySpecialistsSurgeryValvularSyndromeFollowDirect relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis
Yousef S, Amabile A, Ram C, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Krane M, Geirsson A, Vallabhajosyula P. Direct relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis. Journal Of Cardiac Surgery 2022, 37: 5052-5062. PMID: 36378856, DOI: 10.1111/jocs.17199.Peer-Reviewed Original ResearchConceptsDegree of ASCardiac structural changesAortic stenosisSevere symptomatic aortic stenosisEnd-organ morbiditiesStructural cardiac changesSymptomatic aortic stenosisEnd-organ diseaseKaplan-Meier curvesRisk of mortalityTransvalvular flow velocityCochran-Armitage testCause mortalityPatient characteristicsCardiac changesCardiac dysfunctionPatient morbidityTransvalvular velocityCurrent guidelinesGroup BGroup ACaucasian raceHigh riskCox modelEarly intervention
2021
Survival of Patients With Mild Secondary Mitral Regurgitation With and Without Mild Tricuspid Regurgitation
Mori M, Weininger G, Agarwal R, Shang M, Amabile A, Kahler-Quesada A, Yousef S, Pichert M, Vallabhajosyula P, Zhang Y, Sugeng L, Geirsson A. Survival of Patients With Mild Secondary Mitral Regurgitation With and Without Mild Tricuspid Regurgitation. Canadian Journal Of Cardiology 2021, 37: 1513-1521. PMID: 34119634, DOI: 10.1016/j.cjca.2021.06.005.Peer-Reviewed Original ResearchConceptsMild secondary mitral regurgitationLeft ventricular ejection fractionSecondary mitral regurgitationMild tricuspid regurgitationNormal left ventricular ejection fractionTricuspid regurgitationHazard of deathGroup 1Valvular abnormalitiesMitral regurgitationGroup 2Mean age 61 yearsGroup 4Cox proportional hazards modelGroup 1 patientsGroup 2 patientsGroup 3 patientsGroup 4 patientsAge 61 yearsRetrospective cohort studySurvival of patientsSubgroup of patientsProportional hazards modelCohort studyHealth care network