Dynamical and integrative cell signaling: challenges for the new biology
Levchenko A. Dynamical and integrative cell signaling: challenges for the new biology. Biotechnology And Bioengineering 2003, 84: 773-782. PMID: 14708118, DOI: 10.1002/bit.10854.Peer-Reviewed Original ResearchConceptsProtein-centric approachSystems biology approachSignal transduction pathwaysNeural networkHigh-fidelity informationCareful experimental analysisBiology approachStatic worldTransduction pathwaysCell signalingPostgenomic eraHigh-throughput analysisIntracellular networksNetworkComplex networksNew biologyVolatile environmentBiological researchNotion of concentrationStructural viewBiochemical reactionsDynamical viewExperimental analysisPathwayPrimary determinant