2003
Allovalency: A Case of Molecular Entanglement
Levchenko A. Allovalency: A Case of Molecular Entanglement. Current Biology 2003, 13: r876-r878. PMID: 14614843, DOI: 10.1016/j.cub.2003.10.049.Peer-Reviewed Original Research
2000
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties
Levchenko A, Bruck J, Sternberg P. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 5818-5823. PMID: 10823939, PMCID: PMC18517, DOI: 10.1073/pnas.97.11.5818.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseScaffold proteinProtein kinaseSpecific cellular contextDifferent subcellular compartmentsDetailed biochemical modelCellular contextSignal transductionSubcellular compartmentsScaffold concentrationsScaffold levelMultimolecular complexesFull activationGeneric scaffoldKinaseProteinBiochemical modelPathwaySignal propagationTransductionComplexesQuantitative computer modelCrosstalkCompartmentsActivation