2016
CSIG-05. PUTTING THE BRAKES ON BRACHYURY: IDENTIFYING AND TARGETING A CONSERVED TRANSCRIPTIONAL NETWORK THAT DRIVES PRIMARY AND METASTATIC TUMOR INITIATION AND PROPAGATION
Shah S, David J, Tippens N, Mohyeldin A, Martinez J, Ganaha S, Levchenko A, Palena C, Quinones-Hinojosa A. CSIG-05. PUTTING THE BRAKES ON BRACHYURY: IDENTIFYING AND TARGETING A CONSERVED TRANSCRIPTIONAL NETWORK THAT DRIVES PRIMARY AND METASTATIC TUMOR INITIATION AND PROPAGATION. Neuro-Oncology 2016, 18: vi41-vi41. DOI: 10.1093/neuonc/now212.166.Peer-Reviewed Original ResearchTranscriptional networksTranscriptional programsGenetic inhibitorsT-box transcription factorCell transcriptional programDirect transcriptional activationCell cycle progressionNew molecular insightsMalignant neoplasmsNegative feedback loopEarly embryogenesisTranscriptional activationHippo pathwayOrgan developmentTranscription factorsMaster regulatorProtein stabilityBioinformatics analysisGenetic stabilityPrevalent lung cancerCycle progressionMetastatic brain tumorsMolecular underpinningsMolecular insightsBrachyury
2006
Transcription Factor NF‐κ B: Function, Structure, Regulation, Pathways, and Applications
Cheong R, Levchenko A. Transcription Factor NF‐κ B: Function, Structure, Regulation, Pathways, and Applications. 2006 DOI: 10.1002/3527600906.mcb.200500006.Peer-Reviewed Original ResearchTranscription factor subunitNF-κBTranscription factor NFPosttranslation modificationsSignal transductionTranscription factorsFactor subunitTarget genesCombinatorial specificityRel familyStress responseGreat therapeutic interestFactor NFIκB kinaseNF-κB activityMost cellsNumerous mechanismsSubunitsCentral roleTherapeutic interestInhibitorsTransductionKinaseGenesCytoplasm