Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells
Levchenko A, Mehta B, Niu X, Kang G, Villafania L, Way D, Polycarpe D, Sadelain M, Larson S. Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 1933-1938. PMID: 15671173, PMCID: PMC545583, DOI: 10.1073/pnas.0401851102.Peer-Reviewed Original ResearchConceptsFunctional P-gpP-gpTumor cellsMultidrug resistanceP-gp-mediated resistanceP-gp-negative cellsToxic drug concentrationsP-gp-positive cellsIntercellular transferResistant tumor cellsDifferent tumor cell typesTumor cell typesTumor massTumor stromaP-gp transferTumor typesP-glycoproteinStromal elementsDrug resistanceDrug concentrationsTumor samplesBiologic propertiesCancer therapyCell typesCells