2005
Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells
Levchenko A, Mehta B, Niu X, Kang G, Villafania L, Way D, Polycarpe D, Sadelain M, Larson S. Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 1933-1938. PMID: 15671173, PMCID: PMC545583, DOI: 10.1073/pnas.0401851102.Peer-Reviewed Original ResearchConceptsFunctional P-gpP-gpTumor cellsMultidrug resistanceP-gp-mediated resistanceP-gp-negative cellsToxic drug concentrationsP-gp-positive cellsIntercellular transferResistant tumor cellsDifferent tumor cell typesTumor cell typesTumor massTumor stromaP-gp transferTumor typesP-glycoproteinStromal elementsDrug resistanceDrug concentrationsTumor samplesBiologic propertiesCancer therapyCell typesCells
2000
Evaluation of 11C-colchicine for PET imaging of multiple drug resistance.
Levchenko A, Mehta B, Lee J, Humm J, Augensen F, Squire O, Kothari P, Finn R, Leonard E, Larson S. Evaluation of 11C-colchicine for PET imaging of multiple drug resistance. Journal Of Nuclear Medicine 2000, 41: 493-501. PMID: 10716325.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Carbon RadioisotopesColchicineDrug Resistance, MultipleFlow CytometryHumansMiceMice, Inbred BALB CModels, TheoreticalNeuroblastomaRatsRats, NudeTissue DistributionTomography, Emission-ComputedTransplantation, HeterologousTumor Cells, CulturedConceptsResistant tumorsPET imagingMultiple drug resistance phenotypeDrug-resistant variantsQuality of lifeCell linesMultiple drug resistanceResistant cell linesC cell lineP-gp actionDrug resistance phenotypeEarly diagnosisNude ratsFDG scansTumorsP-glycoproteinDrug resistanceBiodistribution experimentsCytotoxic agentsChemotherapeutic interventionResistant strainsCancer cellsIntracellular accumulationVivo experimentsScans