CSIG-05. PUTTING THE BRAKES ON BRACHYURY: IDENTIFYING AND TARGETING A CONSERVED TRANSCRIPTIONAL NETWORK THAT DRIVES PRIMARY AND METASTATIC TUMOR INITIATION AND PROPAGATION
Shah S, David J, Tippens N, Mohyeldin A, Martinez J, Ganaha S, Levchenko A, Palena C, Quinones-Hinojosa A. CSIG-05. PUTTING THE BRAKES ON BRACHYURY: IDENTIFYING AND TARGETING A CONSERVED TRANSCRIPTIONAL NETWORK THAT DRIVES PRIMARY AND METASTATIC TUMOR INITIATION AND PROPAGATION. Neuro-Oncology 2016, 18: vi41-vi41. DOI: 10.1093/neuonc/now212.166.Peer-Reviewed Original ResearchTranscriptional networksTranscriptional programsGenetic inhibitorsT-box transcription factorCell transcriptional programDirect transcriptional activationCell cycle progressionNew molecular insightsMalignant neoplasmsNegative feedback loopEarly embryogenesisTranscriptional activationHippo pathwayOrgan developmentTranscription factorsMaster regulatorProtein stabilityBioinformatics analysisGenetic stabilityPrevalent lung cancerCycle progressionMetastatic brain tumorsMolecular underpinningsMolecular insightsBrachyury