GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs
Hilioti Z, Gallagher D, Low-Nam S, Ramaswamy P, Gajer P, Kingsbury T, Birchwood C, Levchenko A, Cunningham K. GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Genes & Development 2003, 18: 35-47. PMID: 14701880, PMCID: PMC314273, DOI: 10.1101/gad.1159204.Peer-Reviewed Original ResearchConceptsProtein phosphataseType 1 protein phosphataseGSK-3 kinaseGSK-3 familyConserved serine residueProtein phosphatase activitySerine residuesAnimal cellsConsensus sitesProtein kinaseMuscle developmentPositive feedback loopYeast cellsRCN1CalcineurinMCIP1Phosphatase activityPhosphorylationEndogenous levelsInhibitory formKinaseLarge inductionStimulatory effectHeart growthPhosphatase