2024
Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification
Kang T, Bocci F, Nie Q, Onuchic J, Levchenko A. Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification. ELife 2024, 12: rp89262. PMID: 38376371, PMCID: PMC10942579, DOI: 10.7554/elife.89262.Peer-Reviewed Original ResearchConceptsCell fate specificationFate specificationNotch signalingMorphogenic processesCell-cell communicationComplex morphogenic processesCell fateDynamics of spatial patternsDepletion of fibronectinTip cellsSprout extensionAngiogenic morphogenesisHypoxic micro-environmentCell plasticityCellsComputational analysisPre-existing onesCell patternMicro-environmentSpatial patternsLocal enrichmentMorphogenesisEndothelial cellsAngiogenesis modelFibronectin
2009
Investigating transient and prolonged VEGF signaling through regulation of intracellular calcium
Noren D, Levchenko A, Popel A. Investigating transient and prolonged VEGF signaling through regulation of intracellular calcium. The FASEB Journal 2009, 23: 767.15-767.15. DOI: 10.1096/fasebj.23.1_supplement.767.15.Peer-Reviewed Original ResearchVascular endothelial growth factorIntracellular calciumEndothelial growth factorVasoactive factorsVascular permeabilityCalcium levelsRapid transient increaseBiphasic responseCalcium releaseNitric oxideTransient increaseEndothelial cellsVEGF receptorsGrowth factorVascular structuresEC proliferationCalciumKey regulatorVEGF stimulation