TM-01IDENTIFICATION OF GLUCOSE-6-PHOSPHATASE ALPHA AS A KEY METABOLIC REGULATOR FOR GLIOBLASTOMA CELL INVASION
Abbadi S, Rodarte J, Abutaleb A, Lavell E, Smith C, Ruff W, Schiller J, Olivi A, Levchenko A, Guerrero-Cazares H, Quinones-Hinojosa A. TM-01IDENTIFICATION OF GLUCOSE-6-PHOSPHATASE ALPHA AS A KEY METABOLIC REGULATOR FOR GLIOBLASTOMA CELL INVASION. Neuro-Oncology 2014, 16: v213-v213. PMCID: PMC4218619, DOI: 10.1093/neuonc/nou278.1.Peer-Reviewed Original ResearchBrain tumor initiating cellsGlycolytic inhibitionGlioblastoma cell invasionSuch reprogrammingKnockdown cellsMetabolic reprogrammingTumor initiating cellsKey enzymeGlycogen synthaseCell survivalAggressive primary brain cancerCell invasionComplete rescueFunctional consequencesPotential therapeutic targetPrimary brain cancerGBM cellsWild-type miceG6PCReprogrammingInitiating cellsGlycogen accumulationGlycogen phosphorylaseMalignant progressionKnockdown