2023
Fingerprints of decreased cognitive performance on fractal connectivity dynamics in healthy aging
Kaposzta Z, Czoch A, Mukli P, Stylianou O, Liu D, Eke A, Racz F. Fingerprints of decreased cognitive performance on fractal connectivity dynamics in healthy aging. GeroScience 2023, 46: 713-736. PMID: 38117421, PMCID: PMC10828149, DOI: 10.1007/s11357-023-01022-x.Peer-Reviewed Original ResearchHealthy elderly individualsHealthy agingFunctional connectivityElderly individualsConnectivity strengthCognitive performanceBrain functional connectivityDynamic functional connectivity studiesFuture intervention strategiesFunctional connectivity studiesAge-related cognitive declineCognitive performance scoresResponse latencyElderly populationCognitive declineAge groupsSubject cohortYounger groupCognitive functionPotential targetSpearman correlationSubset of connectionsIntervention strategiesElectroencephalography recordingsFunctional connectionsResting-state fractal brain connectivity is associated with impaired cognitive performance in healthy aging
Czoch A, Kaposzta Z, Mukli P, Stylianou O, Eke A, Racz F. Resting-state fractal brain connectivity is associated with impaired cognitive performance in healthy aging. GeroScience 2023, 46: 473-489. PMID: 37458934, PMCID: PMC10828136, DOI: 10.1007/s11357-023-00836-z.Peer-Reviewed Original ResearchAge-related cognitive declineCognitive performanceCognitive declineBrain connectivityHealthy agingImpaired cognitive performanceComprehensive cognitive evaluationFunctional brain connectivityYoung control participantsVisual memoryAttention domainFrontoparietal connectionsTask performanceCognitive evaluationNeurophysiological markersMental workloadCognitive functionNeurophysiological basisControl participantsResponse latencyBrain regionsElectroencephalography (EEG) measurementsReduced performanceReaction timeEEG data
2022
Scale-Free Functional Brain Networks Exhibit Increased Connectivity, Are More Integrated and Less Segregated in Patients with Parkinson’s Disease following Dopaminergic Treatment
Stylianou O, Kaposzta Z, Czoch A, Stefanovski L, Yabluchanskiy A, Racz F, Ritter P, Eke A, Mukli P. Scale-Free Functional Brain Networks Exhibit Increased Connectivity, Are More Integrated and Less Segregated in Patients with Parkinson’s Disease following Dopaminergic Treatment. Fractal And Fractional 2022, 6: 737. PMID: 38106971, PMCID: PMC10723163, DOI: 10.3390/fractalfract6120737.Peer-Reviewed Original ResearchHealthy control individualsMini-Mental State ExaminationDopaminergic treatmentParkinson's diseaseFunctional connectivityMental State ExaminationStandard therapyPD patientsPD populationHC groupState ExaminationFunctional brain networksControl individualsPharmacological studiesSignificant positive correlationDiseaseBrain networksPatientsCognitive performanceAdult Reading TestPositive correlationTreatmentLong-term memoryTherapyReal-Time Algorithm for Detrended Cross-Correlation Analysis of Long-Range Coupled Processes
Kaposzta Z, Czoch A, Stylianou O, Kim K, Mukli P, Eke A, Racz F. Real-Time Algorithm for Detrended Cross-Correlation Analysis of Long-Range Coupled Processes. Frontiers In Physiology 2022, 13: 817268. PMID: 35360238, PMCID: PMC8963246, DOI: 10.3389/fphys.2022.817268.Peer-Reviewed Original ResearchMental state monitoringReal timeState monitoringReal-time acquisitionExecution timeOnline algorithmOffline variantFast algorithmTime algorithmAlgorithmPearson cross-correlation coefficientParallel estimationCoupled ProcessesDiverse fieldsEntire signalAnalysis techniquesCross-correlation coefficientSet of signalsNon-stationary signalsMultiple-Resampling Cross-Spectral Analysis: An Unbiased Tool for Estimating Fractal Connectivity With an Application to Neurophysiological Signals
Racz F, Czoch A, Kaposzta Z, Stylianou O, Mukli P, Eke A. Multiple-Resampling Cross-Spectral Analysis: An Unbiased Tool for Estimating Fractal Connectivity With an Application to Neurophysiological Signals. Frontiers In Physiology 2022, 13: 817239. PMID: 35321422, PMCID: PMC8936508, DOI: 10.3389/fphys.2022.817239.Peer-Reviewed Original Research
2021
Multifractal Functional Connectivity Analysis of Electroencephalogram Reveals Reorganization of Brain Networks in a Visual Pattern Recognition Paradigm
Stylianou O, Racz F, Kim K, Kaposzta Z, Czoch A, Yabluchanskiy A, Eke A, Mukli P. Multifractal Functional Connectivity Analysis of Electroencephalogram Reveals Reorganization of Brain Networks in a Visual Pattern Recognition Paradigm. Frontiers In Human Neuroscience 2021, 15: 740225. PMID: 34733145, PMCID: PMC8558231, DOI: 10.3389/fnhum.2021.740225.Peer-Reviewed Original ResearchFunctional connectivityHigher-order brain functionsFunctional connectivity analysisEyes-open stateBrain reorganizationHealthy volunteersBrain regionsBrain functionBrain connectivityDiseased populationsAnatomical networksSuccess rateFunctional couplingBrain networksEndpoint parametersNeuronal assembliesHuman brainConnectivity analysisObserved regional heterogeneityRecognition trialsLevelsRegional heterogeneityBrainTrialsRecognition paradigmCorrigendum: Two-Tiered Response of Cardiorespiratory-Cerebrovascular Network to Orthostatic Challenge
Mukli P, Nagy Z, Racz F, Portoro I, Hartmann A, Stylianou O, Debreczeni R, Bereczki D, Eke A. Corrigendum: Two-Tiered Response of Cardiorespiratory-Cerebrovascular Network to Orthostatic Challenge. Frontiers In Physiology 2021, 12: 685417. PMID: 33967839, PMCID: PMC8098711, DOI: 10.3389/fphys.2021.685417.Peer-Reviewed Original ResearchTwo-Tiered Response of Cardiorespiratory-Cerebrovascular Network to Orthostatic Challenge
Mukli P, Nagy Z, Racz F, Portoro I, Hartmann A, Stylianou O, Debreczeni R, Bereczki D, Eke A. Two-Tiered Response of Cardiorespiratory-Cerebrovascular Network to Orthostatic Challenge. Frontiers In Physiology 2021, 12: 622569. PMID: 33737882, PMCID: PMC7960776, DOI: 10.3389/fphys.2021.622569.Peer-Reviewed Original ResearchArterial blood pressureCerebral hemodynamicsBlood pressureOrthostatic stressPostural changesCerebral blood flow velocityHigh-pressure baroreflexesHomeostatic mechanismsPair-wise Pearson correlationBlood flow velocityYoung healthy adultsKey homeostatic mechanismCerebral autoregulationOrthostatic challengeCerebrovascular dynamicsHealthy adultsBreath intervalNon-invasive measurementHemodynamicsTwo-tiered responseHbT signalsOxygenationPhysiological perturbationsPearson correlationPhysiological systemsScale-Free Coupled Dynamics in Brain Networks Captured by Bivariate Focus-Based Multifractal Analysis
Stylianou O, Racz F, Eke A, Mukli P. Scale-Free Coupled Dynamics in Brain Networks Captured by Bivariate Focus-Based Multifractal Analysis. Frontiers In Physiology 2021, 11: 615961. PMID: 33613302, PMCID: PMC7887319, DOI: 10.3389/fphys.2020.615961.Peer-Reviewed Original ResearchSeparating scale‐free and oscillatory components of neural activity in schizophrenia
Racz F, Farkas K, Stylianou O, Kaposzta Z, Czoch A, Mukli P, Csukly G, Eke A. Separating scale‐free and oscillatory components of neural activity in schizophrenia. Brain And Behavior 2021, 11: e02047. PMID: 33538105, PMCID: PMC8119820, DOI: 10.1002/brb3.2047.Peer-Reviewed Original Research
2020
Decreased connection density and modularity of functional brain networks during n‐back working memory paradigm
Kaposzta Z, Stylianou O, Mukli P, Eke A, Racz F. Decreased connection density and modularity of functional brain networks during n‐back working memory paradigm. Brain And Behavior 2020, 11: e01932. PMID: 33185986, PMCID: PMC7821619, DOI: 10.1002/brb3.1932.Peer-Reviewed Original ResearchMultifractal and Entropy-Based Analysis of Delta Band Neural Activity Reveals Altered Functional Connectivity Dynamics in Schizophrenia
Racz F, Stylianou O, Mukli P, Eke A. Multifractal and Entropy-Based Analysis of Delta Band Neural Activity Reveals Altered Functional Connectivity Dynamics in Schizophrenia. Frontiers In Systems Neuroscience 2020, 14: 49. PMID: 32792917, PMCID: PMC7394222, DOI: 10.3389/fnsys.2020.00049.Peer-Reviewed Original ResearchModel-based evaluation of the microhemodynamic effects of PEGylated HBOC molecules in the rat brain cortex: a laser speckle imaging study.
Portörő I, Mukli P, Kocsis L, Hermán P, Caccia D, Perrella M, Mozzarelli A, Ronda L, Mathe D, Eke A. Model-based evaluation of the microhemodynamic effects of PEGylated HBOC molecules in the rat brain cortex: a laser speckle imaging study. Biomedical Optics Express 2020, 11: 4150-4175. PMID: 32923034, PMCID: PMC7449705, DOI: 10.1364/boe.388089.Peer-Reviewed Original ResearchHemoglobin-based oxygen carriersLaser speckle contrastSpeckle contrastSpatial dispersionAdverse effectsEuro-pegInfrared ImagingRed blood cell velocityRat brain cortexBlood cell velocityPotential adverse effectsNitric oxide scavengingVascular resistanceAdverse eventsBrain microcirculationBrain cortexFractional changeTissue hematocritPlatelet aggregationImaging studiesCell velocityClinical applicationSignificant differencesExtravasationDispersionEditorial: Fractal and Multifractal Facets in the Structure and Dynamics of Physiological Systems and Applications to Homeostatic Control, Disease Diagnosis and Integrated Cyber-Physical Platforms
Bogdan P, Eke A, Ivanov P. Editorial: Fractal and Multifractal Facets in the Structure and Dynamics of Physiological Systems and Applications to Homeostatic Control, Disease Diagnosis and Integrated Cyber-Physical Platforms. Frontiers In Physiology 2020, 11: 447. PMID: 32477161, PMCID: PMC7239033, DOI: 10.3389/fphys.2020.00447.Peer-Reviewed Original Research
2019
Multifractal and entropy analysis of resting-state electroencephalography reveals spatial organization in local dynamic functional connectivity
Racz F, Stylianou O, Mukli P, Eke A. Multifractal and entropy analysis of resting-state electroencephalography reveals spatial organization in local dynamic functional connectivity. Scientific Reports 2019, 9: 13474. PMID: 31530857, PMCID: PMC6748940, DOI: 10.1038/s41598-019-49726-5.Peer-Reviewed Original ResearchConceptsDynamic functional connectivityFunctional connectivityResting-state brain activityResting-state electroencephalography recordingsFuture clinical researchResting-state electroencephalographyResting-state conditionsFunctional network topologyRegion-specific differencesHealthy subjectsPotential biomarkersBrain regionsClinical researchTemporal regionsOccipital regionBrain activityElectroencephalography recordingsBrainDFC analysisBiomarkers
2018
Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute
Cooper C, Silkstone G, Simons M, Rajagopal B, Syrett N, Shaik T, Gretton S, Welbourn E, Bülow L, Eriksson N, Ronda L, Mozzarelli A, Eke A, Mathe D, Reeder B. Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute. Free Radical Biology And Medicine 2018, 134: 106-118. PMID: 30594736, PMCID: PMC6597946, DOI: 10.1016/j.freeradbiomed.2018.12.030.Peer-Reviewed Original ResearchConceptsTyrosine residuesΒ-subunitSingle tyrosine mutationsFerryl heme speciesOxidative stressExtracellular proteinsTyrosine mutationWild typePromising mutantsHEK cellsProtein surfaceHeme speciesMutationsMembrane damageRedox-active tyrosine residueHeme reductionOxidative toxicityFerryl speciesFerric HbSubunitsHb additionHeme lossSpeciesProteinFerric formMultifractal Dynamic Functional Connectivity in the Resting-State Brain
Racz F, Stylianou O, Mukli P, Eke A. Multifractal Dynamic Functional Connectivity in the Resting-State Brain. Frontiers In Physiology 2018, 9: 1704. PMID: 30555345, PMCID: PMC6284038, DOI: 10.3389/fphys.2018.01704.Peer-Reviewed Original ResearchImpact of Healthy Aging on Multifractal Hemodynamic Fluctuations in the Human Prefrontal Cortex
Mukli P, Nagy Z, Racz FS, Herman P, Eke A. Impact of Healthy Aging on Multifractal Hemodynamic Fluctuations in the Human Prefrontal Cortex. Frontiers In Physiology 2018, 9: 1072. PMID: 30147657, PMCID: PMC6097581, DOI: 10.3389/fphys.2018.01072.Peer-Reviewed Original ResearchCerebral hemodynamicsHemodynamic fluctuationsElderly groupCerebral hemodynamic fluctuationsNon-neuronal componentsMajority of subjectsNeurovascular couplingElderly subjectsHuman prefrontal cortexHealthy volunteersBrain cortexHemodynamic influenceYounger groupNeural functionPrefrontal cortexHealthy agingHemodynamicsNeural activitySlow componentCortexMultifractal dynamics of resting-state functional connectivity in the prefrontal cortex
Racz F, Mukli P, Nagy Z, Eke A. Multifractal dynamics of resting-state functional connectivity in the prefrontal cortex. Physiological Measurement 2018, 39: 024003. PMID: 29350187, DOI: 10.1088/1361-6579/aaa916.Peer-Reviewed Original Research
2017
Decomposing Multifractal Crossovers
Nagy Z, Mukli P, Herman P, Eke A. Decomposing Multifractal Crossovers. Frontiers In Physiology 2017, 8: 533. PMID: 28798694, PMCID: PMC5527813, DOI: 10.3389/fphys.2017.00533.Peer-Reviewed Original Research