2018
Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute
Cooper C, Silkstone G, Simons M, Rajagopal B, Syrett N, Shaik T, Gretton S, Welbourn E, Bülow L, Eriksson N, Ronda L, Mozzarelli A, Eke A, Mathe D, Reeder B. Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute. Free Radical Biology And Medicine 2018, 134: 106-118. PMID: 30594736, PMCID: PMC6597946, DOI: 10.1016/j.freeradbiomed.2018.12.030.Peer-Reviewed Original ResearchConceptsTyrosine residuesΒ-subunitSingle tyrosine mutationsFerryl heme speciesOxidative stressExtracellular proteinsTyrosine mutationWild typePromising mutantsHEK cellsProtein surfaceHeme speciesMutationsMembrane damageRedox-active tyrosine residueHeme reductionOxidative toxicityFerryl speciesFerric HbSubunitsHb additionHeme lossSpeciesProteinFerric form
1977
The protecting action of a combination of vasoactivating substances (CRP) on disturbances of the cerebral blood flow and metabolism and the cortical electrical activity (author's transl).
Dora E, Gyulay L, Kovach A, Eke A. The protecting action of a combination of vasoactivating substances (CRP) on disturbances of the cerebral blood flow and metabolism and the cortical electrical activity (author's transl). Drug Research 1977, 27: 108-11. PMID: 192249.Peer-Reviewed Original ResearchConceptsBlood flowMean arterial pressureDirect cortical stimulationCerebral blood flowBlood pressure dropCortical electrical activityArterial pressureCortical stimulationHemorrhagic shockNormal animalsEffects of anoxiaBeneficial effectsElectrical activityBrain circulationCortical cellsOxygen supplyFurther evidenceMetabolism
1976
Correlation between the Redox State, Electrical Activity and Blood Flow in Cat Brain CORTEX During Hemorrhagic Shock
Kovách A, Eke A, Dóra E, Gyulai L. Correlation between the Redox State, Electrical Activity and Blood Flow in Cat Brain CORTEX During Hemorrhagic Shock. Advances In Experimental Medicine And Biology 1976, 75: 289-297. PMID: 189584, DOI: 10.1007/978-1-4684-3273-2_35.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCatsCerebral CortexElectroencephalographyElectrophysiologyHypotensionHypoxiaNADOxidation-ReductionRegional Blood FlowShock, Hemorrhagic