2023
Structural and functional asymmetry of the neonatal cerebral cortex
Williams L, Fitzgibbon S, Bozek J, Winkler A, Dimitrova R, Poppe T, Schuh A, Makropoulos A, Cupitt J, O’Muircheartaigh J, Duff E, Cordero-Grande L, Price A, Hajnal J, Rueckert D, Smith S, Edwards A, Robinson E. Structural and functional asymmetry of the neonatal cerebral cortex. Nature Human Behaviour 2023, 7: 942-955. PMID: 36928781, DOI: 10.1038/s41562-023-01542-8.Peer-Reviewed Original ResearchConceptsCortical asymmetryHealthy term-born neonatesNeonatal cerebral cortexTerm-born neonatesTerm-equivalent ageHealthy young adultsHuman Connectome ProjectPreterm birthPreterm neonatesNeonatal cortexCerebral cortexTerm cohortFunctional magnetic resonance imagesMagnetic resonance imagesConnectome ProjectBrain asymmetryYoung adultsSignificant differencesNeonatesResonance imagesFunctional asymmetryCortexBirthBiological sexCohort
2022
Shared brain and genetic architectures between mental health and physical activity
Zhang W, Paul S, Winkler A, Bogdan R, Bijsterbosch J. Shared brain and genetic architectures between mental health and physical activity. Translational Psychiatry 2022, 12: 428. PMID: 36192376, PMCID: PMC9530213, DOI: 10.1038/s41398-022-02172-w.Peer-Reviewed Original ResearchConceptsPhysical activityMental healthConnectivity strengthPhysical activity measuresSelf-reported mental health measuresMental health measuresPhysical activity modelBrain network architectureLatent causal variable analysisAccelerometer-derived measuresHealth measuresActivity measuresBeneficial effectsBiological correlatesUK BiobankCausal relationshipBrain mechanismsNeural correlatesHealthLinkage disequilibrium score regressionSimilar loading patternsBrainPutative causal relationshipDisequilibrium score regressionForms of psychopathology
2019
Combining fMRI during resting state and an attention bias task in children
Harrewijn A, Abend R, Linke J, Brotman M, Fox N, Leibenluft E, Winkler A, Pine D. Combining fMRI during resting state and an attention bias task in children. NeuroImage 2019, 205: 116301. PMID: 31639510, PMCID: PMC6911838, DOI: 10.1016/j.neuroimage.2019.116301.Peer-Reviewed Original ResearchConceptsDot-probe taskAttention bias taskFunctional connectivityThreat biasBias taskCognitive tasksDifferent attentional processesReconfiguration efficiencyTask-based fMRI dataAttentional processesAttention taskSocial reticenceTask performanceAttention stateAnxiety symptomsFMRI dataPattern of modulationPrior researchTaskIQFMRICurrent studyChildrenFunctional hierarchyNetwork changesStrategy-dependent modulation of cortical pain circuits for the attenuation of pain
Schulz E, Stankewitz A, Witkovský V, Winkler A, Tracey I. Strategy-dependent modulation of cortical pain circuits for the attenuation of pain. Cortex 2019, 113: 255-266. PMID: 30711854, DOI: 10.1016/j.cortex.2018.12.014.Peer-Reviewed Original ResearchConceptsCognitive strategiesBrain activityDifferent cognitive strategiesPain attenuationUnderlying neuronal mechanismsPain-related brain activityVariability of performanceNeuroscientific techniquesNeurofeedback techniquesT fMRIPerception of painBehavioral dataBehavioral studiesTrial levelBrain regionsCortical regionsNeuronal mechanismsCortical feedbackInsular cortexDistractionTaskPain perceptionPotential predispositionAttenuation of painPerception
2017
The heritability of multi-modal connectivity in human brain activity
Colclough G, Smith S, Nichols T, Winkler A, Sotiropoulos S, Glasser M, Van Essen D, Woolrich M. The heritability of multi-modal connectivity in human brain activity. ELife 2017, 6: e20178. PMID: 28745584, PMCID: PMC5621837, DOI: 10.7554/elife.20178.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMagnetic resonance imagingFunctional connectivity profilesNeuronal activityResonance imagingCortical regionsFunctional connectivityFMRI connectivityGenetic factorsConnectivity profilesMagnetoencephalographic recordingsBrain activityCognitive performanceHuman brain activityHuman Connectome ProjectMulti-modal connectivityConnectome ProjectDisease
2015
A positive-negative mode of population covariation links brain connectivity, demographics and behavior
Smith S, Nichols T, Vidaurre D, Winkler A, Behrens T, Glasser M, Ugurbil K, Barch D, Van Essen D, Miller K. A positive-negative mode of population covariation links brain connectivity, demographics and behavior. Nature Neuroscience 2015, 18: 1565-1567. PMID: 26414616, PMCID: PMC4625579, DOI: 10.1038/nn.4125.Peer-Reviewed Original ResearchHeritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data
Kochunov P, Jahanshad N, Marcus D, Winkler A, Sprooten E, Nichols TE, Wright SN, Hong LE, Patel B, Behrens T, Jbabdi S, Andersson J, Lenglet C, Yacoub E, Moeller S, Auerbach E, Ugurbil K, Sotiropoulos SN, Brouwer RM, Landman B, Lemaitre H, Braber A, Zwiers MP, Ritchie S, van Hulzen K, Almasy L, Curran J, deZubicaray GI, Duggirala R, Fox P, Martin NG, McMahon KL, Mitchell B, Olvera RL, Peterson C, Starr J, Sussmann J, Wardlaw J, Wright M, Boomsma DI, Kahn R, de Geus EJ, Williamson DE, Hariri A, van 't Ent D, Bastin ME, McIntosh A, Deary IJ, pol H, Blangero J, Thompson PM, Glahn DC, Van Essen DC. Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data. NeuroImage 2015, 111: 300-311. PMID: 25747917, PMCID: PMC4387079, DOI: 10.1016/j.neuroimage.2015.02.050.Peer-Reviewed Original Research
2014
Permutation inference for the general linear model
Winkler AM, Ridgway GR, Webster MA, Smith SM, Nichols TE. Permutation inference for the general linear model. NeuroImage 2014, 92: 381-397. PMID: 24530839, PMCID: PMC4010955, DOI: 10.1016/j.neuroimage.2014.01.060.Peer-Reviewed Original ResearchConceptsPermutation inferenceNon-standard statisticsComplex general linear modelArbitrary experimental designsLinear modelPermutation methodOnly weak assumptionsGLM parametersWeak assumptionsSymmetric distributionExact controlGeneral linear modelNuisance variablesInferenceDetailed exampleComplete algorithmAlgorithmExperimental designIndependent dataNuisance effectsUseful caseGeneric frameworkModelStatisticsGLM
2012
Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regions