2020
The effects of an aerobic training intervention on cognition, grey matter volumes and white matter microstructure
Sexton C, Betts J, Dennis A, Doherty A, Leeson P, Holloway C, Dall'Armellina E, Winkler A, Demnitz N, Wassenaar T, Dawes H, Johansen-Berg H. The effects of an aerobic training intervention on cognition, grey matter volumes and white matter microstructure. Physiology & Behavior 2020, 223: 112923. PMID: 32474233, PMCID: PMC7378567, DOI: 10.1016/j.physbeh.2020.112923.Peer-Reviewed Original ResearchConceptsAerobic training programGray matter volumeCardiorespiratory fitnessMatter volumeMagnetic resonance imaging outcomesSpecific high-risk populationsBrain structuresOlder adultsAerobic training interventionHigh-risk populationStructural MRI analysisTract-based spatial statisticsVoxel-based morphometryVoxel-wise assessmentWaitlist control conditionHealthy older adultsWhite matter microstructureImaging outcomesHippocampal volumeObservational studyPhysical activityReduced riskCognitive declineMax testingMore encouraging results
2017
Associations between self‐reported sleep quality and white matter in community‐dwelling older adults: A prospective cohort study
Sexton C, Zsoldos E, Filippini N, Griffanti L, Winkler A, Mahmood A, Allan C, Topiwala A, Kyle S, Spiegelhalder K, Singh‐Manoux A, Kivimaki M, Mackay C, Johansen‐Berg H, Ebmeier K. Associations between self‐reported sleep quality and white matter in community‐dwelling older adults: A prospective cohort study. Human Brain Mapping 2017, 38: 5465-5473. PMID: 28745016, PMCID: PMC5655937, DOI: 10.1002/hbm.23739.Peer-Reviewed Original ResearchConceptsWhite matter microstructurePoor sleep qualitySleep qualityPoor sleep quality groupSelf-reported sleep qualitySmall effect sizesCommunity-dwelling membersHum Brain MappDiffusion tensorRadial diffusivity valuesVoxel-wise analysisWhite matter measuresCurrent sleep qualityEffect sizeGlobal fractional anisotropyModifiable factorsLifestyle measuresSleep disturbancesPoor sleepSub studyGeneral cognitive functionNeurological illnessAxial diffusivityCognitive functionFractional anisotropy