2020
Ultra-high field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain
Schulz E, Stankewitz A, Winkler A, Irving S, Witkovský V, Tracey I. Ultra-high field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain. ELife 2020, 9: e55028. PMID: 32876049, PMCID: PMC7498261, DOI: 10.7554/elife.55028.Peer-Reviewed Original ResearchConceptsPain attenuationBrain connectivityAttenuation of painCognitive strategiesHigher functional connectivityWhole-brain connectivityTonic cold painWhite matter integrityPain processingLower painFunctional imaging dataCold painPainCingulate cortexBrain regionsFunctional connectivityHealthy participantsTrialsCognitive interventionsDiffusion tensorTrial variabilityBrain dataImaging dataParticipants
2015
Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance‐use disorders performing a go/no‐go task
Acheson A, Tagamets M, Winkler A, Rowland L, Mathias C, Wright S, Hong L, Kochunov P, Dougherty D. Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance‐use disorders performing a go/no‐go task. Brain And Behavior 2015, 5: e00352. PMID: 26221573, PMCID: PMC4511289, DOI: 10.1002/brb3.352.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAspartic AcidBrain MappingChildCorpus StriatumExecutive FunctionFamilyFemaleGenetic Predisposition to DiseaseHumansInhibition, PsychologicalLongitudinal StudiesMagnetic Resonance ImagingMaleMotor CortexNeural PathwaysProton Magnetic Resonance SpectroscopyPsychomotor PerformanceSignal Processing, Computer-AssistedSubstance-Related DisordersWhite MatterConceptsSupplementary motor areaSubstance use disordersWhite matter integrityFamily historyFrontal white matter integrityStriatal activityDorsal striatumFrontal cortical activityCortical activitySMA activityFrontal cortical projectionsDrug use disordersDorsal striatal activitySuch family historyDorsal striatum activityCortical projectionsMotor areaElevated riskOngoing longitudinal studyUse disordersWhite matterDownstream projectionsGo/
2014
Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders
Acheson A, Wijtenburg S, Rowland L, Winkler A, Gaston F, Mathias C, Fox P, Lovallo W, Wright S, Hong L, Dougherty D, Kochunov P. Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders. Human Brain Mapping 2014, 35: 5401-5413. PMID: 24867528, PMCID: PMC4206569, DOI: 10.1002/hbm.22559.Peer-Reviewed Original ResearchConceptsSubstance use disordersLower FA valuesFamily historyUse disordersFA valuesCorona radiataWhole-brain white matter integrityYoung adultsFrontostriatal white matter tractsBrain white matter integrityFrontal white matterPosterior corona radiataAnterior corona radiataFractional anisotropy (FA) dataHigher radial diffusivitySuch family historyWhite matter tractsWhite matter integrityAge-related declineImpaired myelinationAxonal myelinationCorpus callosumGeneral populationWhite matterSignificant negative correlation
2012
Testing the Hypothesis of Accelerated Cerebral White Matter Aging in Schizophrenia and Major Depression
Kochunov P, Glahn DC, Rowland LM, Olvera RL, Winkler A, Yang YH, Sampath H, Carpenter WT, Duggirala R, Curran J, Blangero J, Hong LE. Testing the Hypothesis of Accelerated Cerebral White Matter Aging in Schizophrenia and Major Depression. Biological Psychiatry 2012, 73: 482-491. PMID: 23200529, PMCID: PMC3645491, DOI: 10.1016/j.biopsych.2012.10.002.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMDD cohortAge-related declineFractional anisotropyWM tractsFA valuesAge interactionMain outcome measuresCerebral white matterPathophysiology of schizophreniaAverage fractional anisotropyWhite matter integrityCerebral WMMajor WM tractsMDD patientsDepressive disorderMajor depressionOutcome measuresFunctional declineSCZ patientsWhite matterCohortPeak myelinationPatientsWM FA valuesDefault mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regions