2025
Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents
Kanel D, Zugman A, Stohr G, Scheinberg B, Cardinale E, Winkler A, Kircanski K, Fox N, Brotman M, Linke J, Pine D. Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents. Journal Of Mood And Anxiety Disorders 2025, 9: 100094. DOI: 10.1016/j.xjmad.2024.100094.Peer-Reviewed Original ResearchStructure-function couplingNegative affectFronto-parietal control networkMeasures of psychopathologyDevelopment of psychopathologyResting-state functional MRIDomain-specific factorsTreatment-seeking youthGroup of adolescentsMultimodal MRI methodsTransdiagnostic groupsFunctional network reorganizationBifactor modelPsychopathologyFunctional MRIFunctional connectivityBrain connectivityStudy of brain connectivityPsychological outcomesFunctional connectivity matricesControl networkNetwork reorganizationAffectAdolescentsAnxiety
2024
Task-Rest Reconfiguration Efficiency of the Reward Network Across Adolescence and its Association With Early Life Stress and Depressive Symptoms
Lee Y, Yuan J, Winkler A, Kircanski K, Pine D, Gotlib I. Task-Rest Reconfiguration Efficiency of the Reward Network Across Adolescence and its Association With Early Life Stress and Depressive Symptoms. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024 PMID: 38878818, DOI: 10.1016/j.jaac.2024.04.018.Peer-Reviewed Original ResearchEarly life stressReward networkDepressive symptomsLife stressReconfiguration efficiencyFunctional connectivityExperiences of early life stressExposure to early life stressEffects of early life stressTask-based fMRI scansHigher levels of depressive symptomsLevels of depressive symptomsSevere early life stressReward processingAge-related associationsFMRI scanningAdolescent depressionCommunity sampleTask demandsResting-stateAsymptomatic youthOlder adolescentsEffects of ageRewardBrain statesNeural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study
Filippi C, Winkler A, Kanel D, Elison J, Hardiman H, Sylvester C, Pine D, Fox N. Neural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 9: 905-914. PMID: 38641209, PMCID: PMC11381178, DOI: 10.1016/j.bpsc.2024.03.008.Peer-Reviewed Original ResearchBrain-behavior associationsParent-report measuresInfant temperamentNetwork pairsDorsal attention network connectivityAssessment of infant temperamentParent-reported temperamentAttention network connectivityControl network connectivitySocial anxietyFMRI studyNeural correlatesNeural basisFunctional connectivityParent reportNeuroimaging dataTemperamentAttention-controlComposite scoreDistressNetwork connectivityObservational assessmentNegative associationBehavior estimationDorsalLongitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders
Roelofs E, Bas-Hoogendam J, Winkler A, van der Wee N, Vermeiren R. Longitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders. Neuroscience Applied 2024, 3: 104090. DOI: 10.1016/j.nsa.2024.104090.Peer-Reviewed Original ResearchRight laterobasal amygdalaLaterobasal amygdalaWhole-brain networksAmygdala subregionsFunctional connectivityCentromedial amygdalaSymptom changeFrontal poleInternalizing disordersPostcentral gyrusResting-state functional magnetic resonance imagingResting-state functional connectivityFunctional magnetic resonance imagingICA-derived networksClinically representative sampleFC developmentNonspecific treatment effectsRs-fMRI scansIndependent component analysisResting-state networksLongitudinal developmentCare-as-usualComorbid anxietyNeuroimaging researchBilateral seeds
2022
Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks
Salvan P, Fonseca M, Winkler A, Beauchamp A, Lerch J, Johansen-Berg H. Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks. Nature Neuroscience 2022, 26: 53-63. PMID: 36522497, PMCID: PMC9829536, DOI: 10.1038/s41593-022-01213-3.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSerotonin neuronsSerotonin receptorsSerotonin regulationDorsal raphe serotonin neuronsReceptor networkResting-state functional magnetic resonance imagingOptogenetic functional magnetic resonance imagingRaphe serotonin neuronsSpecific serotonin receptorsBrain-wide activityFunctional magnetic resonance imagingSerotonin receptor typesDifferent serotonin receptorsBrain-wide distributionSerotonin effectsReceptor typesResonance imagingFunctional connectivityReceptorsNeuronsSingle-cell levelCompelling evidenceFunctional signaturesMultiple aspectsThreat imminence reveals links among unfolding of anticipatory physiological response, cortical-subcortical intrinsic functional connectivity, and anxiety
Abend R, Ruiz S, Bajaj M, Harrewijn A, Linke J, Atlas L, Winkler A, Pine D. Threat imminence reveals links among unfolding of anticipatory physiological response, cortical-subcortical intrinsic functional connectivity, and anxiety. Neurobiology Of Stress 2022, 16: 100428. PMID: 35036479, PMCID: PMC8749274, DOI: 10.1016/j.ynstr.2022.100428.Peer-Reviewed Original ResearchThreat imminenceAnticipatory physiological responsesAnxiety effectsPathological anxietyResting-state functional connectivity dataNon-painful thermal stimulationThreat-anticipation taskAnticipation of threatVentromedial prefrontal cortexIntrinsic functional connectivityFunctional connectivity dataDefensive responsesCortical-subcortical circuitsBasic neuroscience researchAnticipatory respondingPhysiological respondingDefensive respondingFear responsesMultivariate network analysisIntrinsic connectivityPrefrontal cortexAnxiety patientsNeuroscience researchPhysiological responsesFunctional connectivity
2020
Amygdala Functional Connectivity and Negative Reactive Temperament at Age 4 Months
Filippi C, Ravi S, Bracy M, Winkler A, Sylvester C, Pine D, Fox N. Amygdala Functional Connectivity and Negative Reactive Temperament at Age 4 Months. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 1137-1146. PMID: 33385507, PMCID: PMC8239057, DOI: 10.1016/j.jaac.2020.11.021.Peer-Reviewed Original ResearchConceptsAmygdala connectivityPositive affectNegative affectParent reportChild-reported anxiety symptomsCognitive control mechanismsFunctional magnetic resonance imagingWhole-brain voxelwise approachLow positive affectAmygdala functional connectivityResting-state functional magnetic resonance imagingIndependent longitudinal samplesReactivity assessmentTemperamental riskReactive temperamentInfant temperamentAnxiety symptomsConnectivity correlatesLongitudinal sampleFunctional connectivityMaternal reportsNegative reactivityAffectTemperamentDistressUltra-high field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain
Schulz E, Stankewitz A, Winkler A, Irving S, Witkovský V, Tracey I. Ultra-high field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain. ELife 2020, 9: e55028. PMID: 32876049, PMCID: PMC7498261, DOI: 10.7554/elife.55028.Peer-Reviewed Original ResearchConceptsPain attenuationBrain connectivityAttenuation of painCognitive strategiesHigher functional connectivityWhole-brain connectivityTonic cold painWhite matter integrityPain processingLower painFunctional imaging dataCold painPainCingulate cortexBrain regionsFunctional connectivityHealthy participantsTrialsCognitive interventionsDiffusion tensorTrial variabilityBrain dataImaging dataParticipants
2019
Combining fMRI during resting state and an attention bias task in children
Harrewijn A, Abend R, Linke J, Brotman M, Fox N, Leibenluft E, Winkler A, Pine D. Combining fMRI during resting state and an attention bias task in children. NeuroImage 2019, 205: 116301. PMID: 31639510, PMCID: PMC6911838, DOI: 10.1016/j.neuroimage.2019.116301.Peer-Reviewed Original ResearchConceptsDot-probe taskAttention bias taskFunctional connectivityThreat biasBias taskCognitive tasksDifferent attentional processesReconfiguration efficiencyTask-based fMRI dataAttentional processesAttention taskSocial reticenceTask performanceAttention stateAnxiety symptomsFMRI dataPattern of modulationPrior researchTaskIQFMRICurrent studyChildrenFunctional hierarchyNetwork changes
2017
The heritability of multi-modal connectivity in human brain activity
Colclough G, Smith S, Nichols T, Winkler A, Sotiropoulos S, Glasser M, Van Essen D, Woolrich M. The heritability of multi-modal connectivity in human brain activity. ELife 2017, 6: e20178. PMID: 28745584, PMCID: PMC5621837, DOI: 10.7554/elife.20178.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMagnetic resonance imagingFunctional connectivity profilesNeuronal activityResonance imagingCortical regionsFunctional connectivityFMRI connectivityGenetic factorsConnectivity profilesMagnetoencephalographic recordingsBrain activityCognitive performanceHuman brain activityHuman Connectome ProjectMulti-modal connectivityConnectome ProjectDisease
2016
Investigating resting-state functional connectivity in the cervical spinal cord at 3T
Eippert F, Kong Y, Winkler A, Andersson J, Finsterbusch J, Büchel C, Brooks J, Tracey I. Investigating resting-state functional connectivity in the cervical spinal cord at 3T. NeuroImage 2016, 147: 589-601. PMID: 28027960, PMCID: PMC5315056, DOI: 10.1016/j.neuroimage.2016.12.072.Peer-Reviewed Original ResearchConceptsCervical spinal cordSpinal cord injurySpinal cordVentral hornCord injuryResting-state functional connectivityMagnetic resonance imaging studyResting-state connectivityResonance imaging studyFunctional magnetic resonance imaging studyLevel-dependent signalHealthy human participantsNon-human primatesDorsal hornDisease progressionTreatment responseEffects of pathologyNeurological conditionsSpinal segmentsResting-state signalsImaging studiesCordFunctional connectivitySpinal componentsSpontaneous fluctuationsTime related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation
Klaassens B, Rombouts S, Winkler A, van Gorsel H, van der Grond J, van Gerven J. Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation. Human Brain Mapping 2016, 38: 308-325. PMID: 27622387, PMCID: PMC5215384, DOI: 10.1002/hbm.23362.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainBrain MappingCholinergic AgentsCholinesterase InhibitorsCitalopramCross-Over StudiesDouble-Blind MethodFemaleGalantamineHumansHydrocortisoneImage Processing, Computer-AssistedMaleModels, NeurologicalOxygenProlactinSelective Serotonin Reuptake InhibitorsSerotoninYoung AdultConceptsFunctional magnetic resonance imagingState functional magnetic resonance imagingSelf-referential mechanismCognitive performanceNeurotransmitter systemsVisual perceptionAcetylcholinesterase inhibitor galantamineSelective serotonin reuptake inhibitor citalopramSerotonin reuptake inhibitor citalopramFunctional connectivityRs-fMRI scansSensorimotor networkReuptake inhibitor citalopramBrain neurotransmitter systemsFunctional networksPsychopharmacological researchHealthy young volunteersTime-specific effectsMagnetic resonance imagingGroup comparisonsState networksCrossover studySerotonergic stimulationAcute influenceHeart rate
2012
Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regions
2010
Genetic control over the resting brain
Glahn DC, Winkler AM, Kochunov P, Almasy L, Duggirala R, Carless MA, Curran JC, Olvera RL, Laird AR, Smith SM, Beckmann CF, Fox PT, Blangero J. Genetic control over the resting brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 1223-1228. PMID: 20133824, PMCID: PMC2824276, DOI: 10.1073/pnas.0909969107.Peer-Reviewed Original ResearchConceptsDefault-mode functional connectivityDefault mode connectivityFunctional connectivityDefault mode networkGenetic factorsPosterior cingulate/precuneus regionBasal neural activityResting-state brain networksGray matter densityMedial prefrontal cortexLeft parahippocampal regionIntrinsic brain functionPsychiatric illnessNeurological illnessNeurophysiologic mechanismsAnatomic variationsRight cerebellumSuch illnessesParahippocampal regionBrain functionPrecuneus regionsPrefrontal cortexIllnessGenetic riskNeural activity