2023
Country-level gender inequality is associated with structural differences in the brains of women and men
Zugman A, Alliende L, Medel V, Bethlehem R, Seidlitz J, Ringlein G, Arango C, Arnatkevičiūtė A, Asmal L, Bellgrove M, Benegal V, Bernardo M, Billeke P, Bosch-Bayard J, Bressan R, Busatto G, Castro M, Chaim-Avancini T, Compte A, Costanzi M, Czepielewski L, Dazzan P, de la Fuente-Sandoval C, Di Forti M, Díaz-Caneja C, Díaz-Zuluaga A, Du Plessis S, Duran F, Fittipaldi S, Fornito A, Freimer N, Gadelha A, Gama C, Garani R, Garcia-Rizo C, Campo C, Gonzalez-Valderrama A, Guinjoan S, Holla B, Ibañez A, Ivanovic D, Jackowski A, Leon-Ortiz P, Lochner C, López-Jaramillo C, Luckhoff H, Massuda R, McGuire P, Miyata J, Mizrahi R, Murray R, Ozerdem A, Pan P, Parellada M, Phahladira L, Ramirez-Mahaluf J, Reckziegel R, Marques T, Reyes-Madrigal F, Roos A, Rosa P, Salum G, Scheffler F, Schumann G, Serpa M, Stein D, Tepper A, Tiego J, Ueno T, Undurraga J, Undurraga E, Valdes-Sosa P, Valli I, Villarreal M, Winton-Brown T, Yalin N, Zamorano F, Zanetti M, cVEDA, Winkler A, Pine D, Evans-Lacko S, Crossley N, Murthy P, Chakrabarti A, Basu D, Subodh B, Singh L, Singh R, Kalyanram K, Kartik K, Kumaran K, Krishnaveni G, Kuriyan R, Kurpad S, Barker G, Bharath R, Desrivieres S, Purushottam M, Orfanos D, Sharma E, Hickman M, Heron J, Toledano M, Vaidya N. Country-level gender inequality is associated with structural differences in the brains of women and men. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2218782120. PMID: 37155867, PMCID: PMC10193926, DOI: 10.1073/pnas.2218782120.Peer-Reviewed Original ResearchConceptsWorse outcomesCaudal anterior cingulateRight caudal anterior cingulateRight medial orbitofrontalAdult healthy menBrains of womenMental health problemsLateral occipital cortexHealthy menRegional cortexHigh riskOccipital cortexCortical thicknessCountry-level gender inequalityMedial orbitofrontalMRI scansThinner cortexAnterior cingulateHealth problemsBrain structuresWomen's brainsWomenBrainCortexRight hemisphere
2021
Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group
Harrewijn A, Cardinale E, Groenewold N, Bas-Hoogendam J, Aghajani M, Hilbert K, Cardoner N, Porta-Casteràs D, Gosnell S, Salas R, Jackowski A, Pan P, Salum G, Blair K, Blair J, Hammoud M, Milad M, Burkhouse K, Phan K, Schroeder H, Strawn J, Beesdo-Baum K, Jahanshad N, Thomopoulos S, Buckner R, Nielsen J, Smoller J, Soares J, Mwangi B, Wu M, Zunta-Soares G, Assaf M, Diefenbach G, Brambilla P, Maggioni E, Hofmann D, Straube T, Andreescu C, Berta R, Tamburo E, Price R, Manfro G, Agosta F, Canu E, Cividini C, Filippi M, Kostić M, Munjiza Jovanovic A, Alberton B, Benson B, Freitag G, Filippi C, Gold A, Leibenluft E, Ringlein G, Werwath K, Zwiebel H, Zugman A, Grabe H, Van der Auwera S, Wittfeld K, Völzke H, Bülow R, Balderston N, Ernst M, Grillon C, Mujica-Parodi L, van Nieuwenhuizen H, Critchley H, Makovac E, Mancini M, Meeten F, Ottaviani C, Ball T, Fonzo G, Paulus M, Stein M, Gur R, Gur R, Kaczkurkin A, Larsen B, Satterthwaite T, Harper J, Myers M, Perino M, Sylvester C, Yu Q, Lueken U, Veltman D, Thompson P, Stein D, Van der Wee N, Winkler A, Pine D. Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group. Translational Psychiatry 2021, 11: 502. PMID: 34599145, PMCID: PMC8486763, DOI: 10.1038/s41398-021-01622-1.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderHealthy controlsBrain structuresMain analysisSecondary analysisAnxiety disordersMale healthy controlsVertex-wise cortical thicknessFemale healthy controlsRandom interceptGlobal brain measuresStructural magnetic resonanceCortical surface areaSubcortical brain structuresMedication useYears of educationCortical thicknessSubcortical volumesWorking GroupVentral diencephalonSmall sample sizeBrain measuresInconsistent findingsRight ventral diencephalonMale individuals
2020
Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth
Axelrud L, Simioni A, Pine D, Winkler A, Pan P, Sato J, Zugman A, Parker N, Picon F, Jackowski A, Hoexter M, Barker G, Martinot J, Martinot M, Satterthwaite T, Rohde L, Milham M, Barker E, Salum G. Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth. European Child & Adolescent Psychiatry 2020, 30: 1895-1906. PMID: 33030612, PMCID: PMC9077631, DOI: 10.1007/s00787-020-01653-x.Peer-Reviewed Original ResearchConceptsGeneral psychopathologyCortical thicknessBrain featuresSubcortical volumesMental disordersStructural brain featuresInternal consistencyBrain structural featuresHealthy Brain NetworkPsychiatric disordersAssociation scoreSymptomatic domainsHigh internal consistencyPsychopathology assessmentDisordersBrain networksLow internal consistencyEffect sizeBehavioral phenotypesScoresReplicable associationsPsychopathologyWeighted scoreAssociationReplicable markers
2019
Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure
Abend R, Gold A, Britton J, Michalska K, Shechner T, Sachs J, Winkler A, Leibenluft E, Averbeck B, Pine D. Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure. Biological Psychiatry 2019, 87: 916-925. PMID: 31955915, PMCID: PMC7211142, DOI: 10.1016/j.biopsych.2019.11.006.Peer-Reviewed Original ResearchConceptsSkin conductance responsesConductance responsesBrain structuresThreat conditioningPathological anxietyComparison subjectsPsychophysiological responsesLarger patient samplesPrefrontal cortical thicknessHealthy comparison subjectsStructural magnetic resonance imaging (MRI) dataThreat stimuliAnticipatory respondingExtinction paradigmStimulus typeMagnetic resonance imaging dataWide age rangeCortical thicknessPatientsNeurodevelopmental changesAnticipatory responsesTranslational advancesStructural brainAdult populationPatient samplesShort-interval intracortical inhibition is decreased in restless legs syndrome across a range of severity
Magalhães S, Queiroz de Paiva J, Kaelin-Lang A, Sterr A, Eckeli A, Winkler A, Fernandes do Prado G, Amaro E, Conforto A. Short-interval intracortical inhibition is decreased in restless legs syndrome across a range of severity. Sleep Medicine 2019, 62: 34-42. PMID: 31539846, DOI: 10.1016/j.sleep.2019.03.021.Peer-Reviewed Original ResearchConceptsShort-interval intracortical inhibitionRLS/WEDCortical thicknessIntracortical inhibitionRestless legs syndrome/Willis-Ekbom diseaseRestless legs syndromePrimary motor cortexWillis-Ekbom diseaseCharacteristic curve analysisGray matter thicknessDiscrimination of participantsIdiopathic mildRange of severityLegs syndromeMotor cortexMagnetic resonance imaging dataMild symptomsSurface-based analysisSeverity ScaleCortical areasMagnetic stimulationWhole brainCurve analysisCharacteristic curveSeverity
2012
Poster #46 GREY MATTER DENSITY AND CORTICAL THICKNESS VARY WITH DIFFERENT ORBITOFRONTAL SULCOGYRAL PATTERNS
Chakirova G, Moorhead T, Whalley H, Sussmann J, Glahn D, Winkler A, Welch K, Giles S, Stanfield A, Brown V, Hall J, Johnstone E, Lawrie S, McIntosh A. Poster #46 GREY MATTER DENSITY AND CORTICAL THICKNESS VARY WITH DIFFERENT ORBITOFRONTAL SULCOGYRAL PATTERNS. Schizophrenia Research 2012, 136: s202. DOI: 10.1016/s0920-9964(12)70618-7.Peer-Reviewed Original Research