2020
White matter structure and myelin-related gene expression alterations with experience in adult rats
Sampaio-Baptista C, Vallès A, Khrapitchev A, Akkermans G, Winkler A, Foxley S, Sibson N, Roberts M, Miller K, Diamond M, Martens G, De Weerd P, Johansen-Berg H. White matter structure and myelin-related gene expression alterations with experience in adult rats. Progress In Neurobiology 2020, 187: 101770. PMID: 32001310, PMCID: PMC7086231, DOI: 10.1016/j.pneurobio.2020.101770.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingAdult ratsMRNA expressionMyelin basic protein mRNA expressionWM plasticityNeuronal activity modulationMBP protein expressionC-fos mRNA expressionMatter structuresAnalysis of myelinGray matter structuresProtein mRNA expressionWhite matter plasticityRegulation of myelinationWhite matter structuresBarrel cortexGene expression alterationsCortical activityMRNA expression analysisRNA sequencing analysisBrain structuresTensor imagingDTI differencesMacroscale measuresMolecular correlates
2015
Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance‐use disorders performing a go/no‐go task
Acheson A, Tagamets M, Winkler A, Rowland L, Mathias C, Wright S, Hong L, Kochunov P, Dougherty D. Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance‐use disorders performing a go/no‐go task. Brain And Behavior 2015, 5: e00352. PMID: 26221573, PMCID: PMC4511289, DOI: 10.1002/brb3.352.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAspartic AcidBrain MappingChildCorpus StriatumExecutive FunctionFamilyFemaleGenetic Predisposition to DiseaseHumansInhibition, PsychologicalLongitudinal StudiesMagnetic Resonance ImagingMaleMotor CortexNeural PathwaysProton Magnetic Resonance SpectroscopyPsychomotor PerformanceSignal Processing, Computer-AssistedSubstance-Related DisordersWhite MatterConceptsSupplementary motor areaSubstance use disordersWhite matter integrityFamily historyFrontal white matter integrityStriatal activityDorsal striatumFrontal cortical activityCortical activitySMA activityFrontal cortical projectionsDrug use disordersDorsal striatal activitySuch family historyDorsal striatum activityCortical projectionsMotor areaElevated riskOngoing longitudinal studyUse disordersWhite matterDownstream projectionsGo/