2023
Cognitive, Behavioral, and Circadian Rhythm Interventions for Insomnia Alter Emotional Brain Responses
Leerssen J, Aghajani M, Bresser T, Rösler L, Winkler A, Foster-Dingley J, Van Someren E. Cognitive, Behavioral, and Circadian Rhythm Interventions for Insomnia Alter Emotional Brain Responses. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 60-69. PMID: 36958474, DOI: 10.1016/j.bpsc.2023.03.007.Peer-Reviewed Original ResearchConceptsAmygdala responseSleep interventionsEmotion-related brain activityFunctional magnetic resonance imaging studyEmotional brain responsesInsomnia treatmentFunctional magnetic resonance imagingCognitive behavioral therapyMagnetic resonance imaging studyEmotional stimuliResonance imaging studyBrain mechanismsIndividual differencesPrevention of depressionCircadian interventionsBrain responsesEmotional stabilityBehavioral therapyAnxiety severityBrain activityBrain responsivenessLeft insulaInsomnia disorderHigh riskInsomnia symptoms
2017
Calcium channel blockade with nimodipine reverses MRI evidence of cerebral oedema following acute hypoxia
Rowland M, Ezra M, Winkler A, Garry P, Lamb C, Kelly M, Okell T, Westbrook J, Wise R, Douaud G, Pattinson K. Calcium channel blockade with nimodipine reverses MRI evidence of cerebral oedema following acute hypoxia. Cerebrovascular And Brain Metabolism Reviews 2017, 39: 285-301. PMID: 28857714, PMCID: PMC6360646, DOI: 10.1177/0271678x17726624.Peer-Reviewed Original ResearchConceptsApparent diffusion coefficientAcute hypoxiaAcute cerebral hypoxiaCalcium channel blockadeCalcium channel antagonismSignificant decreaseCalcium channel antagonistsState functional MRIIntracellular calcium fluxBrain responsesGray matter volumeSame brain regionsEffects of hypoxiaCerebral edemaCerebral hypoxiaNeuronal damageMRI evidenceChannel antagonismCytotoxic edemaChannel antagonistsChannel blockadeClinical conditionsMultiparametric MRIMatter volumeWhole brain