2013
Identification of a Region in the Stalk Domain of the Nipah Virus Receptor Binding Protein That Is Critical for Fusion Activation
Talekar A, DeVito I, Salah Z, Palmer SG, Chattopadhyay A, Rose JK, Xu R, Wilson IA, Moscona A, Porotto M. Identification of a Region in the Stalk Domain of the Nipah Virus Receptor Binding Protein That Is Critical for Fusion Activation. Journal Of Virology 2013, 87: 10980-10996. PMID: 23903846, PMCID: PMC3807285, DOI: 10.1128/jvi.01646-13.Peer-Reviewed Original ResearchMeSH KeywordsCell LineDNA Mutational AnalysisHumansNewcastle disease virusNipah VirusProtein Interaction MappingRecombinant ProteinsViral Envelope ProteinsVirus InternalizationConceptsNewcastle disease virusReceptor binding proteinParamyxovirus fusion activationStalk domainBinding proteinAvian Newcastle disease virusHost cellsViral envelope glycoproteinsFusion activationNiV FEnvelope glycoproteinReceptor binding regionsTarget cellsNipah virusSialic acid moietiesDisease virusFusion signalChimeric proteinMembrane fusionReceptorsGlobular domainFusion proteinAttachment proteinCellular membranesActivation
2012
A Chimeric Vesiculo/Alphavirus Is an Effective Alphavirus Vaccine
Chattopadhyay A, Wang E, Seymour R, Weaver SC, Rose JK. A Chimeric Vesiculo/Alphavirus Is an Effective Alphavirus Vaccine. Journal Of Virology 2012, 87: 395-402. PMID: 23077320, PMCID: PMC3536361, DOI: 10.1128/jvi.01860-12.Peer-Reviewed Original ResearchConceptsChikungunya virusVesicular stomatitis virusChimeric vesicular stomatitis virusAlphavirus vaccinesCellular immune responsesAlphavirus chikungunya virusMosquito-transmitted alphavirusCHIKV glycoproteinsCHIKV infectionCHIKV vaccineLicensed vaccineSingle doseWorldwide epidemicChikungunya feverImmune responseExperimental vaccinesAlphavirus infectionMultiple recent outbreaksVaccineHigh titersChimeric virusesSerious human diseasesVSV glycoproteinVirusRecent outbreak
2010
Complementing Defective Viruses That Express Separate Paramyxovirus Glycoproteins Provide a New Vaccine Vector Approach
Chattopadhyay A, Rose JK. Complementing Defective Viruses That Express Separate Paramyxovirus Glycoproteins Provide a New Vaccine Vector Approach. Journal Of Virology 2010, 85: 2004-2011. PMID: 21177820, PMCID: PMC3067786, DOI: 10.1128/jvi.01852-10.Peer-Reviewed Original Research
2008
Hybrid alphavirus–rhabdovirus propagating replicon particles are versatile and potent vaccine vectors
Rose NF, Publicover J, Chattopadhyay A, Rose JK. Hybrid alphavirus–rhabdovirus propagating replicon particles are versatile and potent vaccine vectors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 5839-5843. PMID: 18391206, PMCID: PMC2311333, DOI: 10.1073/pnas.0800280105.Peer-Reviewed Original ResearchMeSH KeywordsAlphavirusAnimalsAntibodies, ViralAntibody FormationImmunityMiceRepliconRhabdoviridaeRNAVaccinationViral Envelope ProteinsViral VaccinesConceptsCellular immune responsesImmune responseVaccine vectorStrong cellular immune responsesPotent vaccine vectorSubsequent lethal challengeInduction of antibodiesSafe vaccine vectorSingle doseLethal challengeReplicon particlesHigh titersPotent inducerVirus-like particlesViral structural proteinsAntibodiesInfectious particlesCell linesVirus glycoproteinRNA repliconsRNA replicationVesicular stomatitis virus glycoproteinVSVAnimal cell linesStructural proteins