2022
Polypharmacy and medical intensive care unit (MICU) admission and 10-year all-cause mortality risk among hospitalized patients with and without HIV
Gordon KS, Crothers K, Butt AA, Edelman EJ, Gibert C, Pisani MM, Rodriguez-Barradas M, Wyatt C, Justice AC, Akgün KM. Polypharmacy and medical intensive care unit (MICU) admission and 10-year all-cause mortality risk among hospitalized patients with and without HIV. PLOS ONE 2022, 17: e0276769. PMID: 36302039, PMCID: PMC9612570, DOI: 10.1371/journal.pone.0276769.Peer-Reviewed Original ResearchConceptsMedical intensive care unit admissionIntensive care unit admissionCare unit admissionMICU admissionSeverity of illnessHazard ratioHIV statusUnit admissionCause mortalityHospitalized patientsElectronic health record cohortLevel of polypharmacyRetrospective cohort studyCause mortality riskCohort studyHIV infectionCox regressionPolypharmacyMortality riskFiscal year 2009AdmissionPatientsMortalitySubstance useStrong association
2020
Polypharmacy in HIV: recent insights and future directions.
Edelman EJ, Rentsch CT, Justice AC. Polypharmacy in HIV: recent insights and future directions. Current Opinion In HIV And AIDS 2020, 15: 126-133. PMID: 31833963, PMCID: PMC7543953, DOI: 10.1097/coh.0000000000000608.Commentaries, Editorials and LettersConceptsSeverity of illnessInappropriate medicationsDrug interactionsActual adverse eventsSubstance useTotal drug burdenMechanism of injuryElectronic health recordsNonantiretroviral medicationsUpdate findingsMore medicationsAdverse eventsDrug burdenClinical managementPolypharmacyDirect biomarkerMedicationsModifiable mechanismsPWHSicker individualsHealth recordsStrong associationHIVInjuryIllness
2018
Nonantiretroviral polypharmacy and adverse health outcomes among HIV-infected and uninfected individuals
Justice AC, Gordon KS, Skanderson M, Edelman EJ, Akgün KM, Gibert CL, Re V, Rimland D, Womack JA, Wyatt CM, Tate JP, Team V. Nonantiretroviral polypharmacy and adverse health outcomes among HIV-infected and uninfected individuals. AIDS 2018, 32: 739-749. PMID: 29543653, PMCID: PMC5868488, DOI: 10.1097/qad.0000000000001756.Peer-Reviewed Original ResearchConceptsAdverse health outcomesHIV statusUninfected individualsVACS IndexMedication countUS Veterans Affairs Healthcare SystemHealth outcomesVeterans Affairs Healthcare SystemRisk of hospitalizationSeverity of illnessHIV-1 RNAHIV-positive individualsRisk of mortalityDose responseRace/ethnicityPolypharmacyFiscal year 2009HospitalizationMedicationsMortalityHealthcare systemAntiretroviralsOutcomesAssociationRisk
2003
Understanding racial disparities in HIV using data from the veterans aging cohort 3-site study and VA administrative data.
McGinnis KA, Fine MJ, Sharma RK, Skanderson M, Wagner JH, Rodriguez-Barradas MC, Rabeneck L, Justice AC. Understanding racial disparities in HIV using data from the veterans aging cohort 3-site study and VA administrative data. American Journal Of Public Health 2003, 93: 1728-33. PMID: 14534229, PMCID: PMC1448041, DOI: 10.2105/ajph.93.10.1728.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntiretroviral Therapy, Highly ActiveBlack or African AmericanCohort StudiesDisease ManagementFemaleHispanic or LatinoHIV SeropositivityHumansMaleMiddle AgedPatient Acceptance of Health CarePatient ComplianceProportional Hazards ModelsSocioeconomic FactorsSurvival AnalysisUnited StatesUnited States Department of Veterans AffairsVeteransWhite PeopleConceptsWhite veteransClinical managementMinority veteransHealth statusVeterans Aging CohortSeverity of illnessVA administrative dataRace-associated differencesHigh mortality ratePatients' health statusNational administrative dataAdministrative dataPossible etiologiesUS veteransPoor survivalMortality rateAging CohortHIVPoor healthRacial disparitiesVeteransSignificant differencesSurvivalCohortAdherence
2002
Clinical Importance of HIV and Depressive Symptoms Among Veterans with HIV Infection
Kilbourne AM, Justice AC, Rollman BL, McGinnis KA, Rabeneck L, Weissman S, Smola S, Schultz R, Whittle J, Rodriguez‐Barradas M. Clinical Importance of HIV and Depressive Symptoms Among Veterans with HIV Infection. Journal Of General Internal Medicine 2002, 17: 512-520. PMID: 12133141, PMCID: PMC1495073, DOI: 10.1046/j.1525-1497.2002.10803.x.Peer-Reviewed Original ResearchConceptsSevere depressive symptomsIllness severityHIV symptomsDepressive symptomsHIV infectionClinical importanceHIV Symptom IndexEpidemiologic Studies Depression ScaleInfectious disease clinicPatient illness severitySeverity of illnessSignificant depressive symptomsCross-sectional studyVA Medical CenterHealth care providersDepression symptom severityAntiretroviral useDisease clinicViral loadCommon symptomsSymptom IndexDepression statusSymptom frequencyDepression ScaleMedical Center