2019
Medical Intensive Care Unit Admission Among Patients With and Without HIV, Hepatitis C Virus, and Alcohol-Related Diagnoses in the United States
Rentsch CT, Tate JP, Steel T, Butt AA, Gibert CL, Huang L, Pisani M, Soo Hoo GW, Crystal S, Rodriguez-Barradas MC, Brown ST, Freiberg MS, Graber CJ, Kim JW, Rimland D, Justice AC, Fiellin DA, Crothers KA, Akgün KM. Medical Intensive Care Unit Admission Among Patients With and Without HIV, Hepatitis C Virus, and Alcohol-Related Diagnoses in the United States. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 80: 145-151. PMID: 30422912, PMCID: PMC6701630, DOI: 10.1097/qai.0000000000001904.Peer-Reviewed Original ResearchConceptsHepatitis C virusAlcohol-related diagnosesAdmission ratesMICU admissionAdmission riskC virusRelative riskIntensive care unit admission rateMedical intensive care unit admissionAge-adjusted admission ratesHCV mono-infected patientsIntensive care unit admissionVeterans Aging Cohort StudyHCV care providersCare unit admissionAging Cohort StudyAdjusted rate ratiosConfidence intervalsVeterans Health AdministrationUnhealthy alcohol useHIV monoHIV-/HCVUnit admissionCause hospitalizationHCV infection
2018
Provider verification of electronic health record receipt and nonreceipt of direct-acting antivirals for the treatment of hepatitis C virus infection
Rentsch CT, Cartwright EJ, Gandhi NR, Brown ST, Rodriguez-Barradas MC, Goetz MB, Marconi VC, Gibert CL, Re VL, Fiellin DA, Justice AC, Tate JP. Provider verification of electronic health record receipt and nonreceipt of direct-acting antivirals for the treatment of hepatitis C virus infection. Annals Of Epidemiology 2018, 28: 808-811. PMID: 30195616, PMCID: PMC6318448, DOI: 10.1016/j.annepidem.2018.08.007.Peer-Reviewed Original ResearchConceptsHepatitis C virus infectionCorporate Data WarehouseChronic HCV infectionC virus infectionPositive predictive valuePredictive valueHCV infectionHCV treatmentVirus infectionVeterans Health Administration Corporate Data WarehouseChronic hepatitis C virus (HCV) infectionStudy periodModern treatment eraRetrospective cohort studyElectronic health record dataPharmacy fill recordsHealth record dataNegative predictive valueElectronic health recordsAntiviral regimenHCV therapyTreatment eraChart reviewCohort studyAntiviral treatment
2016
Hepatic Safety of Buprenorphine in HIV-Infected and Uninfected Patients With Opioid Use Disorder: The Role of HCV-Infection
Tetrault JM, Tate JP, Edelman EJ, Gordon AJ, Re V, Lim JK, Rimland D, Goulet J, Crystal S, Gaither JR, Gibert CL, Rodriguez-Barradas MC, Fiellin LE, Bryant K, Justice AC, Fiellin DA. Hepatic Safety of Buprenorphine in HIV-Infected and Uninfected Patients With Opioid Use Disorder: The Role of HCV-Infection. Journal Of Substance Use And Addiction Treatment 2016, 68: 62-67. PMID: 27431048, PMCID: PMC4976086, DOI: 10.1016/j.jsat.2016.06.002.Peer-Reviewed Original ResearchConceptsLiver enzyme elevationAlcohol use disorderUninfected patientsHepatotoxic medicationsHCV infectionUse disordersComposite endpointLiver injuryHIV/HCV co-infected patientsHCV co-infected patientsHIV/HCV statusPre-existing liver injuryCo-infected patientsCohort of HIVHepatitis C infectionHIV/HCVOpioid use disorderRisk of hepatotoxicityHCV statusHepatic safetyMedian ALTC infectionChart reviewEnzyme elevationHIV infectionIsolated Hepatitis B Core Antibody is Associated With Advanced Hepatic Fibrosis in HIV/HCV Infection But Not in HIV Infection Alone
Bhattacharya D, Tseng CH, Tate JP, Re V, Gibert CL, Butt AA, Brown ST, Lim JK, Rodriguez-Barradas MC, Rimland D, Kaufman E, Justice AC, Goetz MB. Isolated Hepatitis B Core Antibody is Associated With Advanced Hepatic Fibrosis in HIV/HCV Infection But Not in HIV Infection Alone. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 72: e14-e17. PMID: 26829660, PMCID: PMC4837046, DOI: 10.1097/qai.0000000000000941.Peer-Reviewed Original Research
2011
The Risk of Incident Coronary Heart Disease Among Veterans With and Without HIV and Hepatitis C
Freiberg MS, Chang CC, Skanderson M, McGinnis K, Kuller LH, Kraemer KL, Rimland D, Goetz MB, Butt AA, Barradas M, Gibert C, Leaf D, Brown ST, Samet J, Kazis L, Bryant K, Justice AC. The Risk of Incident Coronary Heart Disease Among Veterans With and Without HIV and Hepatitis C. Circulation Cardiovascular Quality And Outcomes 2011, 4: 425-432. PMID: 21712519, PMCID: PMC3159506, DOI: 10.1161/circoutcomes.110.957415.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHepatitis C virusHIV-HCVCensoring eventVeterans Aging Cohort Study Virtual CohortIncident coronary heart diseaseCoronary heart disease riskHeart disease riskCoronary heart diseaseHIV-1 RNARisk of CHDIncidence of CHDHCV statusVeteran EnrolleesAdjusted riskAntiretroviral therapyCD4 countCHD eventsHCV infectionHepatitis CCHD riskImmunodeficiency virusC virusHeart diseaseRisk factors
2009
Hepatitis C Virus Infection and the Risk of Coronary Disease
Butt AA, Xiaoqiang W, Budoff M, Leaf D, Kuller LH, Justice AC. Hepatitis C Virus Infection and the Risk of Coronary Disease. Clinical Infectious Diseases 2009, 49: 225-232. PMID: 19508169, PMCID: PMC3077953, DOI: 10.1086/599371.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseHepatitis C virus infectionC virus infectionTraditional risk factorsHigh riskHCV infectionControl subjectsRisk factorsVirus infectionRisk of CADMean total plasma cholesterolLow-density lipoprotein cholesterolCox proportional hazards modelHCV Infected VeteransTotal plasma cholesterolFavorable risk profileProportional hazards modelVeterans Affairs facilitiesLower lipid levelsLipoprotein cholesterolObservational cohortRenal failureArtery diseaseCoronary diseaseMultivariable analysis
2006
Hepatocellular Carcinoma and Non-Hodgkin's Lymphoma: The Roles of HIV, Hepatitis C Infection, and Alcohol Abuse
McGinnis KA, Fultz SL, Skanderson M, Conigliaro J, Bryant K, Justice AC. Hepatocellular Carcinoma and Non-Hodgkin's Lymphoma: The Roles of HIV, Hepatitis C Infection, and Alcohol Abuse. Journal Of Clinical Oncology 2006, 24: 5005-5009. PMID: 17075119, DOI: 10.1200/jco.2006.05.7984.Peer-Reviewed Original ResearchConceptsAlcohol abuse/dependenceHIV-negative veteransAbuse/dependenceHIV-positive veteransIncident rate ratiosHepatocellular carcinomaGreater riskVeterans Affairs Healthcare SystemFirst HIV diagnosisHepatitis C infectionPresence of HCVRole of HIVNinth Revision codesNon-Hodgkin lymphomaRelationship of HIVHeavy alcohol useHigher relative incidencePoisson regression modelsC infectionHCV infectionHepatitis CHIV diagnosisHIV statusHodgkin's lymphomaRevision codes
2004
Risk of diabetes in HIV infected veterans pre‐ and post‐HAART and the role of HCV coinfection
Butt AA, Fultz SL, Kwoh CK, Kelley D, Skanderson M, Justice AC. Risk of diabetes in HIV infected veterans pre‐ and post‐HAART and the role of HCV coinfection. Hepatology 2004, 40: 115-119. PMID: 15239093, DOI: 10.1002/hep.20289.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusPre-HAART eraHAART eraRisk of diabetesHCV coinfectionHCV infectionHigh riskHepatitis C virus infectionMultivariate Cox regression analysisVeterans Affairs administrative databasesActive antiretroviral therapyC virus infectionCox regression analysisIncidence of diabetesKaplan-Meier curvesCox regression methodsDiagnosis of diabetesHCV-HIVAntiretroviral therapyHazard ratioLiver diseaseImmunodeficiency virusAdministrative databasesVirus infectionDrug diagnosesAssociation of hypocholesterolaemia with hepatitis C virus infection in HIV‐infected people*
Polgreen P, Fultz S, Justice A, Wagner J, Diekema D, Rabeneck L, Weissman S, Stapleton J. Association of hypocholesterolaemia with hepatitis C virus infection in HIV‐infected people*. HIV Medicine 2004, 5: 144-150. PMID: 15139979, DOI: 10.1111/j.1468-1293.2004.00202.x.Peer-Reviewed Original ResearchConceptsHCV antibody statusHIV exposure categoryTotal cholesterol levelsCholesterol levelsHCV antibodiesHCV infectionAntibody statusExposure categoriesDrug useHepatitis C virus statusHigh-density lipid cholesterolLipid-lowering drug useLow-density lipid cholesterolHepatitis C virus infectionLiver function test resultsLower total cholesterol levelsLipid cholesterolC virus statusHCV-negative subjectsC virus infectionHCV-positive patientsHIV-positive patientsProtease inhibitor useHIV viral loadHIV-negative individuals