2017
Continued Transmission of Zika Virus in Humans in West Africa, 1992–2016
Herrera BB, Chang CA, Hamel DJ, Mboup S, Ndiaye D, Imade G, Okpokwu J, Agbaji O, Bei AK, Kanki PJ. Continued Transmission of Zika Virus in Humans in West Africa, 1992–2016. The Journal Of Infectious Diseases 2017, 215: 1546-1550. PMID: 28398562, PMCID: PMC5853591, DOI: 10.1093/infdis/jix182.Peer-Reviewed Original ResearchGenetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal
Wong W, Griggs AD, Daniels RF, Schaffner SF, Ndiaye D, Bei AK, Deme AB, MacInnis B, Volkman SK, Hartl DL, Neafsey DE, Wirth DF. Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal. Genome Medicine 2017, 9: 5. PMID: 28118860, PMCID: PMC5260019, DOI: 10.1186/s13073-017-0398-0.Peer-Reviewed Original ResearchConceptsPolygenomic infectionsRelatedness of strainsMalaria elimination activitiesPlasmodium falciparum parasitesPublic health interventionsEpidemiology modelFalciparum parasitesHealth interventionsDrug resistanceInfectionParasite populationsConclusionsOur findingsCotransmissionSuperinfection modelElimination activitiesTransmission intensityGenetic relatedness analysisGenetic profileInterventionParasitesMajor contributorPatientsPopulationSuperinfectionThiès
2015
The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity
Tubman VN, Mejia P, Shmukler BE, Bei AK, Alper SL, Mitchell JR, Brugnara C, Duraisingh MT. The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity. Antimicrobial Agents And Chemotherapy 2015, 60: 613-616. PMID: 26459896, PMCID: PMC4704178, DOI: 10.1128/aac.01668-15.Peer-Reviewed Original ResearchConceptsGardos channel inhibitorChannel inhibitorsSickle cell diseaseC57BL/6 miceClinical trialsCell diseaseAntimalarial developmentPlasmodium growthErythrocyte dehydrationGardos channelSenicapocBlood stagesBiochemical profileAntimalarial activityPrimate plasmodiaVitro growthInhibitorsPatientsParasitemiaBlockadeDiseaseMiceTrials