2023
Identification of an in vitro artemisinin-resistant Plasmodium falciparum kelch13 R515K mutant parasite in Senegal
Sene S, Pouye M, Martins R, Diallo F, Mangou K, Bei A, Barry A, Faye O, Ndiaye O, Faye O, Sall A, Lopez-Rubio J, Mbengue A. Identification of an in vitro artemisinin-resistant Plasmodium falciparum kelch13 R515K mutant parasite in Senegal. Frontiers In Parasitology 2023, 2: 1076759. DOI: 10.3389/fpara.2023.1076759.Peer-Reviewed Original ResearchPlasmodium falciparum clinical isolatesRing-stage survival assayArtesunate-amodiaquine treatmentPlasmodium falciparum malaria parasitesSentinel surveillance systemFalciparum malaria parasitesK mutationDifferent healthcare centersWorldwide malaria burdenPersistent feverAntimalarial treatmentMalaria-infected blood samplesMalaria casesMalaria burdenIndex caseBlood samplesHealthcare centersClinical isolatesMalaria parasitesSurvival assaysMutant parasitesSurveillance systemFunctional significanceTreatmentParasites
2012
SNP Genotyping Identifies New Signatures of Selection in a Deep Sample of West African Plasmodium falciparum Malaria Parasites
Amambua-Ngwa A, Park DJ, Volkman SK, Barnes KG, Bei AK, Lukens AK, Sene P, Van Tyne D, Ndiaye D, Wirth DF, Conway DJ, Neafsey DE, Schaffner SF. SNP Genotyping Identifies New Signatures of Selection in a Deep Sample of West African Plasmodium falciparum Malaria Parasites. Molecular Biology And Evolution 2012, 29: 3249-3253. PMID: 22688945, PMCID: PMC3472499, DOI: 10.1093/molbev/mss151.Peer-Reviewed Original ResearchConceptsHigh-density single nucleotide polymorphism arraysRecent selective sweepLocal selection pressuresSignals of selectionDrug resistance lociSingle nucleotide polymorphism arrayHaplotype-based testsPlasmodium falciparum malaria parasitesSelective sweepsResistance lociGenetic diversityGenomic regionsRecent selectionGenomic analysisSelection signalsPositive selectionSelection pressureFalciparum malaria parasitesPolymorphism arrayAntigenic lociMalaria parasitesMosquito vectorsEndemic populationsLociParasites