AML-187: The STIMULUS Clinical Trial Program: Evaluating Combination Therapy with MBG453 in Patients with Higher-Risk Myelodysplastic Syndrome (HR-MDS) or Acute Myeloid Leukemia
Zeidan A, Esteve J, Kim H, Miyazaki Y, Platzbecker U, Schuh A, Westermann J, Malek K, Scott J, Niolat J, Peyrard S, Kiertsman F, Stegert M, Fenaux P. AML-187: The STIMULUS Clinical Trial Program: Evaluating Combination Therapy with MBG453 in Patients with Higher-Risk Myelodysplastic Syndrome (HR-MDS) or Acute Myeloid Leukemia. Clinical Lymphoma Myeloma & Leukemia 2020, 20: s188. DOI: 10.1016/s2152-2650(20)30727-8.Peer-Reviewed Original ResearchHigh-risk myelodysplastic syndromeEvent-free survivalClinical trial programLeukemia-free survivalProgression-free survivalOverall survivalTrial programEligible patientsSecondary endpointsTransfusion independenceCombination therapyAnti-Tim-3 monoclonal antibodyCR/CRi rateMultiple immune cell typesHigher risk MDSMRD negative ratePhase 1b studyOpen-label studyComplete remission rateDouble-blind studyRelapse-free survivalGood safety profileAcute myeloid leukemiaImmune cell typesLeukemic stem cells