The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation
Carley E, Stewart R, Zieman AG, Jalilian I, King DE, Zubek AE, Lin S, Horsley V, King MC. The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation. ELife 2021, 10: e58541. PMID: 33779546, PMCID: PMC8051949, DOI: 10.7554/elife.58541.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationEpidermisFemaleIntegrinsLamin Type AMechanotransduction, CellularMiceNuclear LaminaPlakinsConceptsCell fateEpidermal cell fateLinker of nucleoskeletonCell fate decisionsEpidermal differentiation genesEpidermal differentiationDirect force transmissionEpidermal stem cellsCytoskeleton (LINC) complexLINC complexFate decisionsNuclear laminaType laminsDifferentiation genesIntegrin engagementForce transductionDifferentiation concomitantChemical signalsMechanotransduction pathwaysKeratinocyte progenitorsMolecular biosensorsStem cellsKeratinocyte differentiationDifferentiationMechanical input