2021
The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation
Carley E, Stewart R, Zieman AG, Jalilian I, King DE, Zubek AE, Lin S, Horsley V, King MC. The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation. ELife 2021, 10: e58541. PMID: 33779546, PMCID: PMC8051949, DOI: 10.7554/elife.58541.Peer-Reviewed Original ResearchConceptsCell fateEpidermal cell fateLinker of nucleoskeletonCell fate decisionsEpidermal differentiation genesEpidermal differentiationDirect force transmissionEpidermal stem cellsCytoskeleton (LINC) complexLINC complexFate decisionsNuclear laminaType laminsDifferentiation genesIntegrin engagementForce transductionDifferentiation concomitantChemical signalsMechanotransduction pathwaysKeratinocyte progenitorsMolecular biosensorsStem cellsKeratinocyte differentiationDifferentiationMechanical input
2015
Nuclear–cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions
Stewart RM, Zubek AE, Rosowski KA, Schreiner SM, Horsley V, King MC. Nuclear–cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions. Journal Of Cell Biology 2015, 209: 403-418. PMID: 25963820, PMCID: PMC4427780, DOI: 10.1083/jcb.201502024.Peer-Reviewed Original ResearchConceptsIntercellular adhesionNuclear positionEpidermal tissue integrityLinker of nucleoskeletonCross talkPrimary mouse keratinocytesCytoskeleton (LINC) complexCytoplasmic cytoskeletonAdhesion functionMicrotubule networkDefective adhesionCytoskeletonSUN2Mouse keratinocytesTissue integrityFollicle structureEpidermal keratinocytesAdhesionNucleoskeletonCellsKeratinocytesAdhesion formationNucleusIntegrityComplexes