2012
Maternal separation with early weaning: A rodent model providing novel insights into neglect associated developmental deficits
Carlyle BC, Duque A, Kitchen RR, Bordner KA, Coman D, Doolittle E, Papademetris X, Hyder F, Taylor JR, Simen AA. Maternal separation with early weaning: A rodent model providing novel insights into neglect associated developmental deficits. Development And Psychopathology 2012, 24: 1401-1416. PMID: 23062306, PMCID: PMC3681803, DOI: 10.1017/s095457941200079x.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderPost-traumatic stress disorder symptomsMaternal separationEarly life neglectAttentional deficitsHyperactivity disorderDisorder symptomsLife-long problemsCognitive deficitsBehavioral problemsStress-responsive systemsDevelopmental deficitsChild maltreatmentChild neglectBehavioral deficitsDeficitsBehavioral analysisDrug abuseMost researchNeglectSerious public health concernMagnetic resonance imaging
2011
Neuroanatomical changes in a mouse model of early life neglect
Duque A, Coman D, Carlyle BC, Bordner KA, George ED, Papademetris X, Hyder F, Simen AA. Neuroanatomical changes in a mouse model of early life neglect. Brain Structure And Function 2011, 217: 459-472. PMID: 21984312, PMCID: PMC3664301, DOI: 10.1007/s00429-011-0350-9.Peer-Reviewed Original ResearchConceptsMouse modelNeuroanatomical changesEarly life neglectNovel mouse modelNovel animal modelWhite matter disorganizationMaternal separationCortical thicknessAdult miceAnimal modelsBehavioral abnormalitiesInter-hemispheric asymmetrySmall brain sizeSubcortical structuresPharmacological experimentationProtein expressionLeft hemisphereEarly weaningHuman survivorsAbnormalitiesCurrent knowledgeBrain sizeConcomitant changesAtrophy