Functional Genomic and Proteomic Analysis Reveals Disruption of Myelin-Related Genes and Translation in a Mouse Model of Early Life Neglect
Bordner KA, George ED, Carlyle BC, Duque A, Kitchen RR, Lam TT, Colangelo CM, Stone KL, Abbott TB, Mane SM, Nairn AC, Simen AA. Functional Genomic and Proteomic Analysis Reveals Disruption of Myelin-Related Genes and Translation in a Mouse Model of Early Life Neglect. Frontiers In Psychiatry 2011, 2: 18. PMID: 21629843, PMCID: PMC3098717, DOI: 10.3389/fpsyt.2011.00018.Peer-Reviewed Original ResearchNext-generation RNA sequencingLabel-free proteomicsFunctional genomicsProtein translationProteomic analysisCDNA microarrayMethylation changesRNA sequencingPromoter regionEarly life neglectMethylation analysisGenesMolecular changesProteomicsMature oligodendrocytesGenomicsTranslationDisruption of myelinMouse modelTissue samplesMechanismMicroarrayGood animal modelDysregulation