2024
NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7
Gordon R, Cosgrove H, Marinov A, Gingras S, Tilstra J, Campbell A, Bastacky S, Kashgarian M, Perl A, Nickerson K, Shlomchik M. NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7. JCI Insight 2024, 9: e178563. PMID: 39042716, PMCID: PMC11343599, DOI: 10.1172/jci.insight.178563.Peer-Reviewed Original ResearchSystemic lupus erythematosusB cellsRegulation of TLR7Cell lineagesNADPH oxidaseHematopoietic cell lineagesNF-kB signalingSLE pathologyNOX2 deficiencyMyeloid compartmentMurine lupusLupus nephritisLupus erythematosusTLR7 signalingGlobal deletionInterstitial nephritisImmunomodulatory effectsGlobal knockoutConditional knockoutCYBBNOX2NephritisKnockoutTLR7Chimera approach
2020
Parallels Between the Antiviral State and the Irradiated State
McGee HM, Marciscano AE, Campbell AM, Monjazeb AM, Kaech SM, Teijaro JR. Parallels Between the Antiviral State and the Irradiated State. Journal Of The National Cancer Institute 2020, 113: 969-979. PMID: 33252657, PMCID: PMC8502484, DOI: 10.1093/jnci/djaa190.Peer-Reviewed Original ResearchConceptsHost antiviral defenseType I interferon responseI interferon responseViral mimicryAntiviral defenseHost cellsMolecular pathwaysAntiviral statePathogen controlAntiviral responseViral infectionInterferon responseHost defensePathwayDNADanger signalsAntitumor immunityTumor controlRecent studiesSterile inflammationDefenseTumor cellsTumor DNACellsRNA
2019
Exploring single-cell data with deep multitasking neural networks
Amodio M, van Dijk D, Srinivasan K, Chen WS, Mohsen H, Moon KR, Campbell A, Zhao Y, Wang X, Venkataswamy M, Desai A, Ravi V, Kumar P, Montgomery R, Wolf G, Krishnaswamy S. Exploring single-cell data with deep multitasking neural networks. Nature Methods 2019, 16: 1139-1145. PMID: 31591579, PMCID: PMC10164410, DOI: 10.1038/s41592-019-0576-7.Peer-Reviewed Original Research
2018
Harnessing the Immunomodulatory Effects of Radiation Therapy.
Campbell AM, Decker RH. Harnessing the Immunomodulatory Effects of Radiation Therapy. Oncology 2018, 32: 370-4, cv3. PMID: 30080922.Peer-Reviewed Original ResearchConceptsImmunomodulatory effectsImmune responseImmune systemSetting of cancerSystemic immune responsesAntitumoral immune responseInnate immune systemAdaptive immune systemCell deathTumor cell deathAntitumoral immunityAntitumoral responseHypofractionated radiationRadiotherapy timingProinflammatory responsePreclinical modelsAdaptive immunityRadiation therapyClinical informationRadiation-induced cell deathDoseImmunityDeathPotential superiorityDNA damage
2017
Lupus and proliferative nephritis are PAD4 independent in murine models
Gordon RA, Herter JM, Rosetti F, Campbell AM, Nishi H, Kashgarian M, Bastacky SI, Marinov A, Nickerson KM, Mayadas TN, Shlomchik MJ. Lupus and proliferative nephritis are PAD4 independent in murine models. JCI Insight 2017, 2: e92926. PMID: 28515361, PMCID: PMC5436537, DOI: 10.1172/jci.insight.92926.Peer-Reviewed Original ResearchSystemic lupus erythematosusNeutrophil extracellular trapsProliferative nephritisMurine modelContribution of NETsInhibition of NETsAnti-glomerular basement membrane modelEnd-organ damageLoss of toleranceRecent reportsLupus erythematosusOrgan injuryImmune activationExtracellular trapsPeptidyl arginine deiminasePharmacological approachesBasement membrane modelDistal mediatorsNADPH oxidase complexPharmacological inhibitionNephritisInducible modelLupusNET formationType IV
2016
II-13 Suppression of systemic autoimmunity by the innate immune adaptor sting
Sharma S, Campbell A, Chan J, Schattgen S, Orlowski G, Nayar R, Huyler A, Nündel K, Mohan C, Berg L, Shlomchik M, Marshak-Rothstein A, Fitzgerald K. II-13 Suppression of systemic autoimmunity by the innate immune adaptor sting. 2016, a21.2-a22. DOI: 10.1136/lupus-2016-000179.43.Peer-Reviewed Original Research
2015
Gamma knife stereotactic radiosurgical thalamotomy for intractable tremor: A systematic review of the literature
Campbell AM, Glover J, Chiang VL, Gerrard J, Yu JB. Gamma knife stereotactic radiosurgical thalamotomy for intractable tremor: A systematic review of the literature. Radiotherapy And Oncology 2015, 114: 296-301. PMID: 25690750, DOI: 10.1016/j.radonc.2015.01.013.Peer-Reviewed Original ResearchConceptsStereotactic radiosurgical thalamotomyRadiosurgical thalamotomyIntractable tremorSystematic reviewUnilateral gamma knife thalamotomyOnly available treatment optionGamma knife thalamotomyAvailable treatment optionsSignificant psychological burdenQuality of lifeSurgical candidatesSevere complicationsSurgical treatmentMedical therapyTransient hemiparesisAdverse outcomesTreatment optionsPatient deathStereotactic radiosurgical techniquesMovement disordersLanguage of publicationStereotactic radiosurgeryTreatment efficacyPsychological burdenRadiosurgical techniquesSuppression of systemic autoimmunity by the innate immune adaptor STING
Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e710-e717. PMID: 25646421, PMCID: PMC4343138, DOI: 10.1073/pnas.1420217112.Peer-Reviewed Original ResearchConceptsAutoimmune-prone miceSystemic lupus erythematosusImmune activationSerum cytokine levelsSTING-deficient miceCytosolic DNA-sensing pathwayToll-like receptorsDNA-sensing pathwayCytokine levelsSystemic inflammationLupus erythematosusAutoantibody productionLymphoid hypertrophyTLR ligandsProinflammatory cytokinesAutoimmune pathologySystemic autoimmunityInflammatory macrophagesAdaptor STINGElevated numbersMiceInflammationInterferon genesMacrophagesNegative regulatory role
2012
NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus
Campbell AM, Kashgarian M, Shlomchik MJ. NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus. Science Translational Medicine 2012, 4: 157ra141. PMID: 23100627, PMCID: PMC3704198, DOI: 10.1126/scitranslmed.3004801.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusNeutrophil extracellular trapsLupus erythematosusLupus-prone miceLupus-prone MRLSource of autoantigensLoss of toleranceSelf-nucleic acidsHeterozygous female miceAutoantibody patternsNOX2 deficiencySLE pathologyRenal diseaseAutoantibody profileLupus autoantigensImmune activationAutoimmune diseasesDisease onsetAutoantibody generationFemale miceExtracellular trapsDisease pathogenesisTherapeutic interventionsPhagocyte NADPH oxidaseLupus
2007
Mini-review of conventional and hypofractionated radiation therapy combined with immunotherapy for non-small cell lung cancer
Campbell AM, Decker RH. Mini-review of conventional and hypofractionated radiation therapy combined with immunotherapy for non-small cell lung cancer. Translational Lung Cancer Research 2007, 6: 220-229. PMID: 28529904, PMCID: PMC5420539, DOI: 10.21037/tlcr.2017.03.02.Peer-Reviewed Original ResearchNon-small cell lung cancerCell lung cancerAntitumoral responseAdaptive immune systemLung cancerRadiation therapyImmune systemHypofractionated radiation therapyOngoing clinical trialsDose-fractionation schedulesAssessment of efficacyImmunogenicity of antigensIdentification of biomarkersCell deathAntigenic poolCheckpoint inhibitorsCancer vaccinesCytokine administrationClinical trialsImmunological activationFractionation schedulesRadiation-induced cell deathImmunotherapyActivation statusMonoclonal antibodies