NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus
Campbell AM, Kashgarian M, Shlomchik MJ. NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus. Science Translational Medicine 2012, 4: 157ra141. PMID: 23100627, PMCID: PMC3704198, DOI: 10.1126/scitranslmed.3004801.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusNeutrophil extracellular trapsLupus erythematosusLupus-prone miceLupus-prone MRLSource of autoantigensLoss of toleranceSelf-nucleic acidsHeterozygous female miceAutoantibody patternsNOX2 deficiencySLE pathologyRenal diseaseAutoantibody profileLupus autoantigensImmune activationAutoimmune diseasesDisease onsetAutoantibody generationFemale miceExtracellular trapsDisease pathogenesisTherapeutic interventionsPhagocyte NADPH oxidaseLupus