Suppression of systemic autoimmunity by the innate immune adaptor STING
Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e710-e717. PMID: 25646421, PMCID: PMC4343138, DOI: 10.1073/pnas.1420217112.Peer-Reviewed Original ResearchConceptsAutoimmune-prone miceSystemic lupus erythematosusImmune activationSerum cytokine levelsSTING-deficient miceCytosolic DNA-sensing pathwayToll-like receptorsDNA-sensing pathwayCytokine levelsSystemic inflammationLupus erythematosusAutoantibody productionLymphoid hypertrophyTLR ligandsProinflammatory cytokinesAutoimmune pathologySystemic autoimmunityInflammatory macrophagesAdaptor STINGElevated numbersMiceInflammationInterferon genesMacrophagesNegative regulatory role