2024
NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7
Gordon R, Cosgrove H, Marinov A, Gingras S, Tilstra J, Campbell A, Bastacky S, Kashgarian M, Perl A, Nickerson K, Shlomchik M. NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7. JCI Insight 2024, 9: e178563. PMID: 39042716, PMCID: PMC11343599, DOI: 10.1172/jci.insight.178563.Peer-Reviewed Original ResearchSystemic lupus erythematosusB cellsRegulation of TLR7Cell lineagesNADPH oxidaseHematopoietic cell lineagesNF-kB signalingSLE pathologyNOX2 deficiencyMyeloid compartmentMurine lupusLupus nephritisLupus erythematosusTLR7 signalingGlobal deletionInterstitial nephritisImmunomodulatory effectsGlobal knockoutConditional knockoutCYBBNOX2NephritisKnockoutTLR7Chimera approach
2012
NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus
Campbell AM, Kashgarian M, Shlomchik MJ. NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus. Science Translational Medicine 2012, 4: 157ra141. PMID: 23100627, PMCID: PMC3704198, DOI: 10.1126/scitranslmed.3004801.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusNeutrophil extracellular trapsLupus erythematosusLupus-prone miceLupus-prone MRLSource of autoantigensLoss of toleranceSelf-nucleic acidsHeterozygous female miceAutoantibody patternsNOX2 deficiencySLE pathologyRenal diseaseAutoantibody profileLupus autoantigensImmune activationAutoimmune diseasesDisease onsetAutoantibody generationFemale miceExtracellular trapsDisease pathogenesisTherapeutic interventionsPhagocyte NADPH oxidaseLupus