NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7
Gordon R, Cosgrove H, Marinov A, Gingras S, Tilstra J, Campbell A, Bastacky S, Kashgarian M, Perl A, Nickerson K, Shlomchik M. NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7. JCI Insight 2024, 9: e178563. PMID: 39042716, PMCID: PMC11343599, DOI: 10.1172/jci.insight.178563.Peer-Reviewed Original ResearchSystemic lupus erythematosusB cellsRegulation of TLR7Cell lineagesNADPH oxidaseHematopoietic cell lineagesNF-kB signalingSLE pathologyNOX2 deficiencyMyeloid compartmentMurine lupusLupus nephritisLupus erythematosusTLR7 signalingGlobal deletionInterstitial nephritisImmunomodulatory effectsGlobal knockoutConditional knockoutCYBBNOX2NephritisKnockoutTLR7Chimera approach