2017
Lupus and proliferative nephritis are PAD4 independent in murine models
Gordon RA, Herter JM, Rosetti F, Campbell AM, Nishi H, Kashgarian M, Bastacky SI, Marinov A, Nickerson KM, Mayadas TN, Shlomchik MJ. Lupus and proliferative nephritis are PAD4 independent in murine models. JCI Insight 2017, 2: e92926. PMID: 28515361, PMCID: PMC5436537, DOI: 10.1172/jci.insight.92926.Peer-Reviewed Original ResearchSystemic lupus erythematosusNeutrophil extracellular trapsProliferative nephritisMurine modelContribution of NETsInhibition of NETsAnti-glomerular basement membrane modelEnd-organ damageLoss of toleranceRecent reportsLupus erythematosusOrgan injuryImmune activationExtracellular trapsPeptidyl arginine deiminasePharmacological approachesBasement membrane modelDistal mediatorsNADPH oxidase complexPharmacological inhibitionNephritisInducible modelLupusNET formationType IV
2012
NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus
Campbell AM, Kashgarian M, Shlomchik MJ. NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus. Science Translational Medicine 2012, 4: 157ra141. PMID: 23100627, PMCID: PMC3704198, DOI: 10.1126/scitranslmed.3004801.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusNeutrophil extracellular trapsLupus erythematosusLupus-prone miceLupus-prone MRLSource of autoantigensLoss of toleranceSelf-nucleic acidsHeterozygous female miceAutoantibody patternsNOX2 deficiencySLE pathologyRenal diseaseAutoantibody profileLupus autoantigensImmune activationAutoimmune diseasesDisease onsetAutoantibody generationFemale miceExtracellular trapsDisease pathogenesisTherapeutic interventionsPhagocyte NADPH oxidaseLupus