Reassessment of HIV-1 Acute Phase Infectivity: Accounting for Heterogeneity and Study Design with Simulated Cohorts
Bellan SE, Dushoff J, Galvani AP, Meyers LA. Reassessment of HIV-1 Acute Phase Infectivity: Accounting for Heterogeneity and Study Design with Simulated Cohorts. PLOS Medicine 2015, 12: e1001801. PMID: 25781323, PMCID: PMC4363602, DOI: 10.1371/journal.pmed.1001801.Peer-Reviewed Original ResearchConceptsElevated viral loadAcute phaseViral load trajectoriesSexual network structureViral loadStudy terminationExclusion criteriaRetrospective cohort study designStudy designAcute phase durationSerodiscordant heterosexual couplesRetrospective cohort dataCohort study designProportion of transmissionCourse of infectionRetrospective cohortAntiretroviral treatmentSerodiscordant couplesChronic phaseSimulated cohortRelative hazardCohort dataCohortWide credibility intervalsAdditional risk