Ecological and immunological determinants of influenza evolution
Ferguson NM, Galvani AP, Bush RM. Ecological and immunological determinants of influenza evolution. Nature 2003, 422: 428-433. PMID: 12660783, DOI: 10.1038/nature01509.Peer-Reviewed Original ResearchConceptsNew avian influenzaHost immune systemStrain-transcending immunityImmunological factorsInfluenza ANew vaccinesAnnual epidemicsAntigenic shiftImmune systemAntigenic changesEpidemic formHigh transmissibilityImmunological determinantsInfluenzaAvian influenzaGlobal pandemicInfluenza evolutionViral evolutionViral diversityEpidemiological dynamicsMorbidityVaccineMortalitySubtypesImmunity