2022
Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs
Jing J, Ge W, Struck A, Fernandes M, Hong S, An S, Fatima S, Herlopian A, Karakis I, Halford J, Ng M, Johnson E, Appavu B, Sarkis R, Osman G, Kaplan P, Dhakar M, Jayagopal L, Sheikh Z, Taraschenko O, Schmitt S, Haider H, Kim J, Swisher C, Gaspard N, Cervenka M, Rodriguez Ruiz A, Lee J, Tabaeizadeh M, Gilmore E, Nordstrom K, Yoo J, Holmes M, Herman S, Williams J, Pathmanathan J, Nascimento F, Fan Z, Nasiri S, Shafi M, Cash S, Hoch D, Cole A, Rosenthal E, Zafar S, Sun J, Westover M. Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs. Neurology 2022, 100: e1737-e1749. PMID: 36460472, PMCID: PMC10136018, DOI: 10.1212/wnl.0000000000201670.Peer-Reviewed Original ResearchConceptsGeneralized rhythmic delta activityLateralized rhythmic delta activityLateralized periodic dischargesRhythmic delta activityDelta activityPeriodic dischargesClass II evidencePrimary outcome measureMassachusetts General HospitalContributions of biasCritical illnessSecondary outcomesMedian ageInterrater reliability studyClinical indicationsGeneral HospitalMedian numberOutcome measuresProspective analysisExpert consensusSeizuresBrain monitoringInterrater reliabilityBrain activitySelection bias
2020
Cannabidiol in treatment of refractory epileptic spasms: An open-label study
Herlopian A, Hess EJ, Barnett J, Geffrey AL, Pollack SF, Skirvin L, Bruno P, Sourbron J, Thiele EA. Cannabidiol in treatment of refractory epileptic spasms: An open-label study. Epilepsy & Behavior 2020, 106: 106988. PMID: 32169600, DOI: 10.1016/j.yebeh.2020.106988.Peer-Reviewed Original ResearchConceptsRefractory epileptic spasmsEpileptic spasmsResponder rateAdjunctive therapyCBD treatmentInvestigational new drug trialsOpen-label studyMonths of treatmentSafe adjunctive therapyNew drug trialsInstitutional review boardSubjective reportsBaseline medicationsCBD initiationElectrographic findingsHypsarrhythmia patternClinical responseSeizure frequencyAdverse eventsClinical efficacyElectrographic changesSubjective improvementTarget dosageDrug trialsInitial dosageInterrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms
Jing J, Herlopian A, Karakis I, Ng M, Halford JJ, Lam A, Maus D, Chan F, Dolatshahi M, Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Sun H, Dauwels J, Cole AJ, Hoch DB, Cash SS, Westover MB. Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms. JAMA Neurology 2020, 77: 49-57. PMID: 31633742, PMCID: PMC6806666, DOI: 10.1001/jamaneurol.2019.3531.Peer-Reviewed Original ResearchConceptsInterictal epileptiform dischargesPercentage of agreementEpileptiform dischargesNumber of IEDsMultivariate logistic regression modelPrimary outcome measureMassachusetts General HospitalLogistic regression modelsPhase 1Secondary outcomesInterrater reliability studyRoutine electroencephalogramMedical recordsGeneral HospitalOutcome measuresMAIN OUTCOMEProspective analysisClinical neurophysiologySubspecialty trainingIndividualized thresholdsSubstantial reliabilityInterrater reliabilityNegative controlPhase 2Electroencephalogram
2018
EEG findings in CAR T-cell therapy-related encephalopathy
Herlopian A, Dietrich J, Abramson JS, Cole AJ, Westover MB. EEG findings in CAR T-cell therapy-related encephalopathy. Neurology 2018, 91: 227-229. PMID: 29959264, PMCID: PMC6093761, DOI: 10.1212/wnl.0000000000005910.Peer-Reviewed Original Research
2017
Predictive Value of Electrocorticography in Patients With Mesial Temporal Lobe Epilepsy Undergoing Selective Amygdalohippocampectomy
Herlopian A, Shihabuddin B. Predictive Value of Electrocorticography in Patients With Mesial Temporal Lobe Epilepsy Undergoing Selective Amygdalohippocampectomy. Journal Of Clinical Neurophysiology 2017, 34: 370-374. PMID: 28306691, DOI: 10.1097/wnp.0000000000000376.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyMesial temporal sclerosisTemporal lobe epilepsyPostoperative seizure freedomSelective amygdalohippocampectomyLobe epilepsyIntraoperative electrocorticographySeizure freedomPredictive valueStandard temporal lobectomyNormal brain MRIElectrocorticography findingsSeizure outcomeTemporal sclerosisPostoperative outcomesConsecutive patientsTemporal lobectomyMean durationSingle neurosurgeonRetrospective analysisBrain MRIPatientsEpilepsySeizuresElectrocorticography