2004
CD1d function is regulated by microsomal triglyceride transfer protein
Brozovic S, Nagaishi T, Yoshida M, Betz S, Salas A, Chen D, Kaser A, Glickman J, Kuo T, Little A, Morrison J, Corazza N, Kim JY, Colgan SP, Young SG, Exley M, Blumberg RS. CD1d function is regulated by microsomal triglyceride transfer protein. Nature Medicine 2004, 10: 535-539. PMID: 15107843, DOI: 10.1038/nm1043.Peer-Reviewed Original ResearchConceptsMicrosomal triglyceride transfer proteinIntestinal epithelial cellsT cellsMajor histocompatibility complex class IInvariant NKT cellsInvariant T (MAIT) cellsHistocompatibility complex class INatural killer receptorsGlycolipid antigen presentationComplex class ITransfer proteinInvariant NKTCD1d expressionNKT cellsAntigen presentationKiller receptorsGlycolipid antigensCD1dConditional deletionClass IDistinct subsetsMTTP geneEpithelial cellsHepatocytesEndoplasmic reticulum
2003
Curariform Antagonists Bind in Different Orientations to Acetylcholine-binding Protein*
Gao F, Bern N, Little A, Wang HL, Hansen SB, Talley TT, Taylor P, Sine SM. Curariform Antagonists Bind in Different Orientations to Acetylcholine-binding Protein*. Journal Of Biological Chemistry 2003, 278: 23020-23026. PMID: 12682067, PMCID: PMC3191914, DOI: 10.1074/jbc.m301151200.Peer-Reviewed Original ResearchConceptsAcetylcholine-binding proteinDocking orientationTrp-53Site residuesSubunit interfaceLigand bindingProtein flexibilityAChBPNicotinic acetylcholine receptorsSide chainsTyr-89Binding sitesMutagenesisReceptor binding sitesAcetylcholine receptorsProteinSimilar ligandsDynamic structureBindingStructure-activity relationshipsMolecular dynamics simulationsEquivalent nitrogenComputational methodsStructural levelDistinct orientations