Featured Publications
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease
Little A, Chen P, Vesely M, Khan R, Fiedler J, Garritano J, Islam F, McNiff J, Craft J. HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease. JCI Insight 2023, 8: e166076. PMID: 37526979, PMCID: PMC10543720, DOI: 10.1172/jci.insight.166076.Peer-Reviewed Original ResearchConceptsCutaneous lupus erythematosusLupus skin diseaseT cellsSkin diseasesCytotoxic signatureInflammatory infiltrateHIF-1Tissue damageKidney-infiltrating T cellsSkin-infiltrating T cellsAutoimmune skin diseaseHIF-1 inhibitionSkin tissue damageLupus erythematosusSystemic diseaseTissue inflammationGranzyme BMouse modelInflammatory gene programDiseaseProtein levelsInfiltratesSkin environmentGene programPresent study
2004
CD1d function is regulated by microsomal triglyceride transfer protein
Brozovic S, Nagaishi T, Yoshida M, Betz S, Salas A, Chen D, Kaser A, Glickman J, Kuo T, Little A, Morrison J, Corazza N, Kim JY, Colgan SP, Young SG, Exley M, Blumberg RS. CD1d function is regulated by microsomal triglyceride transfer protein. Nature Medicine 2004, 10: 535-539. PMID: 15107843, DOI: 10.1038/nm1043.Peer-Reviewed Original ResearchConceptsMicrosomal triglyceride transfer proteinIntestinal epithelial cellsT cellsMajor histocompatibility complex class IInvariant NKT cellsInvariant T (MAIT) cellsHistocompatibility complex class INatural killer receptorsGlycolipid antigen presentationComplex class ITransfer proteinInvariant NKTCD1d expressionNKT cellsAntigen presentationKiller receptorsGlycolipid antigensCD1dConditional deletionClass IDistinct subsetsMTTP geneEpithelial cellsHepatocytesEndoplasmic reticulum